ACBP1_CAEEL
ID ACBP1_CAEEL Reviewed; 86 AA.
AC O01805;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Acyl-CoA-binding protein homolog 1;
DE Short=ACBP-1;
DE AltName: Full=Diazepam-binding inhibitor homolog;
DE Short=DBI;
GN Name=acbp-1; ORFNames=C44E4.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Binds medium- and long-chain acyl-CoA esters with very high
CC affinity and may function as an intracellular carrier of acyl-CoA
CC esters. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ACBP family. {ECO:0000305}.
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DR EMBL; FO080862; CCD67306.1; -; Genomic_DNA.
DR PIR; T30954; T30954.
DR RefSeq; NP_491412.1; NM_059011.5.
DR AlphaFoldDB; O01805; -.
DR SMR; O01805; -.
DR BioGRID; 37535; 42.
DR STRING; 6239.C44E4.6.1; -.
DR iPTMnet; O01805; -.
DR EPD; O01805; -.
DR PaxDb; O01805; -.
DR PeptideAtlas; O01805; -.
DR EnsemblMetazoa; C44E4.6.1; C44E4.6.1; WBGene00016655.
DR EnsemblMetazoa; C44E4.6.2; C44E4.6.2; WBGene00016655.
DR GeneID; 172071; -.
DR KEGG; cel:CELE_C44E4.6; -.
DR UCSC; C44E4.6.1; c. elegans.
DR CTD; 172071; -.
DR WormBase; C44E4.6; CE08720; WBGene00016655; acbp-1.
DR eggNOG; KOG0817; Eukaryota.
DR GeneTree; ENSGT00940000173845; -.
DR HOGENOM; CLU_118853_4_1_1; -.
DR InParanoid; O01805; -.
DR OMA; AAQQEYI; -.
DR OrthoDB; 1588000at2759; -.
DR PhylomeDB; O01805; -.
DR PRO; PR:O01805; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00016655; Expressed in adult organism and 3 other tissues.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0036042; F:long-chain fatty acyl-CoA binding; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR GO; GO:0019915; P:lipid storage; IMP:WormBase.
DR CDD; cd00435; ACBP; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR Pfam; PF00887; ACBP; 1.
DR PRINTS; PR00689; ACOABINDINGP.
DR SUPFAM; SSF47027; SSF47027; 1.
DR PROSITE; PS00880; ACB_1; 1.
DR PROSITE; PS51228; ACB_2; 1.
PE 3: Inferred from homology;
KW Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..86
FT /note="Acyl-CoA-binding protein homolog 1"
FT /id="PRO_0000214012"
FT DOMAIN 1..86
FT /note="ACB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT BINDING 13
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 28..32
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 50
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 54
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 73
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
SQ SEQUENCE 86 AA; 9374 MW; 27A9B4FB1B492CAB CRC64;
MTLSFDDAAA TVKTLKTSPS NDELLKLYAL FKQGTVGDNT TDKPGMFDLK GKAKWSAWDE
KKGLAKDDAQ KAYVALVEEL IAKYGA
