ID   TUSC_PHOLL              Reviewed;         119 AA.
AC   Q7N9B6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE   AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN   Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389}; OrderedLocusNames=plu0427;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC       methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC       {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC       TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC       TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00389}.
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DR   EMBL; BX571860; CAE12722.1; -; Genomic_DNA.
DR   RefSeq; WP_011144813.1; NC_005126.1.
DR   AlphaFoldDB; Q7N9B6; -.
DR   SMR; Q7N9B6; -.
DR   STRING; 243265.plu0427; -.
DR   EnsemblBacteria; CAE12722; CAE12722; plu0427.
DR   GeneID; 24168228; -.
DR   KEGG; plu:plu0427; -.
DR   eggNOG; COG2923; Bacteria.
DR   HOGENOM; CLU_155943_1_0_6; -.
DR   OMA; LEMILIM; -.
DR   OrthoDB; 1768076at2; -.
DR   BioCyc; PLUM243265:PLU_RS02080-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1260.10; -; 1.
DR   HAMAP; MF_00389; Thiourid_synth_C; 1.
DR   InterPro; IPR027396; DsrEFH-like.
DR   InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR   InterPro; IPR037450; Sulphur_relay_TusC.
DR   InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR   PANTHER; PTHR38780; PTHR38780; 1.
DR   Pfam; PF02635; DrsE; 1.
DR   SUPFAM; SSF75169; SSF75169; 1.
DR   TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; tRNA processing.
FT   CHAIN           1..119
FT                   /note="Protein TusC"
FT                   /id="PRO_0000234453"
SQ   SEQUENCE   119 AA;  13303 MW;  1F66419B0F53B7E3 CRC64;
     MKKIAFIFTK TPHGDAGGRE GLDALLATSA LTEKVGVFFI SDGVLQLLPN QQPDRILARN
     YIATFKVLPL YDIEECYLCQ EDLVMRGLSS VNHFVLDAKV IPAETIREKL VDYDVVLTF