TUSC_SODGM
ID TUSC_SODGM Reviewed; 119 AA.
AC Q2NQL2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389}; OrderedLocusNames=SG2288;
OS Sodalis glossinidius (strain morsitans).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=343509;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=morsitans;
RX PubMed=16365377; DOI=10.1101/gr.4106106;
RA Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA Aksoy S.;
RT "Massive genome erosion and functional adaptations provide insights into
RT the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL Genome Res. 16:149-156(2006).
CC -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC Rule:MF_00389}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP008232; BAE75563.1; -; Genomic_DNA.
DR RefSeq; WP_011412096.1; NZ_LN854557.1.
DR AlphaFoldDB; Q2NQL2; -.
DR SMR; Q2NQL2; -.
DR STRING; 343509.SG2288; -.
DR EnsemblBacteria; BAE75563; BAE75563; SG2288.
DR KEGG; sgl:SG2288; -.
DR eggNOG; COG2923; Bacteria.
DR HOGENOM; CLU_155943_1_0_6; -.
DR OMA; LEMILIM; -.
DR OrthoDB; 1768076at2; -.
DR BioCyc; SGLO343509:SGP1_RS20895-MON; -.
DR Proteomes; UP000001932; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1260.10; -; 1.
DR HAMAP; MF_00389; Thiourid_synth_C; 1.
DR InterPro; IPR027396; DsrEFH-like.
DR InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR InterPro; IPR037450; Sulphur_relay_TusC.
DR InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR PANTHER; PTHR38780; PTHR38780; 1.
DR Pfam; PF02635; DrsE; 1.
DR SUPFAM; SSF75169; SSF75169; 1.
DR TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE 3: Inferred from homology;
KW Cytoplasm; tRNA processing.
FT CHAIN 1..119
FT /note="Protein TusC"
FT /id="PRO_0000234460"
SQ SEQUENCE 119 AA; 12910 MW; 50F2D256549159D1 CRC64;
MNRIAFVFTH GPHGDAAGRE GLDALLATSA LAEDIGVFFI ADGVLLLLEQ QQPAQILARD
FVATFGVLSL YDVDSLYLCA ESAAERGLDA DAGWVLNAEW LSAADWRQRL SAYDTVMTF