ID   TUSC_YERE8              Reviewed;         121 AA.
AC   A1JS59;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE   AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN   Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389}; OrderedLocusNames=YE3932;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC       methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC       {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC       TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC       TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00389}.
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DR   EMBL; AM286415; CAL13951.1; -; Genomic_DNA.
DR   RefSeq; WP_011817321.1; NC_008800.1.
DR   RefSeq; YP_001008077.1; NC_008800.1.
DR   AlphaFoldDB; A1JS59; -.
DR   SMR; A1JS59; -.
DR   STRING; 393305.YE3932; -.
DR   EnsemblBacteria; CAL13951; CAL13951; YE3932.
DR   KEGG; yen:YE3932; -.
DR   PATRIC; fig|393305.7.peg.4182; -.
DR   eggNOG; COG2923; Bacteria.
DR   HOGENOM; CLU_155943_1_0_6; -.
DR   OMA; LEMILIM; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1260.10; -; 1.
DR   HAMAP; MF_00389; Thiourid_synth_C; 1.
DR   InterPro; IPR027396; DsrEFH-like.
DR   InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR   InterPro; IPR037450; Sulphur_relay_TusC.
DR   InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR   PANTHER; PTHR38780; PTHR38780; 1.
DR   Pfam; PF02635; DrsE; 1.
DR   SUPFAM; SSF75169; SSF75169; 1.
DR   TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; tRNA processing.
FT   CHAIN           1..121
FT                   /note="Protein TusC"
FT                   /id="PRO_1000013246"
SQ   SEQUENCE   121 AA;  13422 MW;  E41ACC60D2911D57 CRC64;
     MAMKCVAFVF TQGPHGNAAG REGLDALLAT SALSENLGVF FLSDGVLQLL PQQQPEKILA
     RNYIATFGVL PLYDVENFYI CEDSLQQRGL SEVTDWILDV EVLSPVNLRR QLANYDVVLT
     F