TUSC_YERPS
ID TUSC_YERPS Reviewed; 121 AA.
AC Q664R2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389}; OrderedLocusNames=YPTB3707;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC Rule:MF_00389}.
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DR EMBL; BX936398; CAH22945.1; -; Genomic_DNA.
DR RefSeq; WP_002212321.1; NZ_CP009712.1.
DR AlphaFoldDB; Q664R2; -.
DR SMR; Q664R2; -.
DR EnsemblBacteria; CAH22945; CAH22945; YPTB3707.
DR GeneID; 66843869; -.
DR KEGG; ypo:BZ17_2880; -.
DR KEGG; yps:YPTB3707; -.
DR PATRIC; fig|273123.14.peg.3021; -.
DR OMA; LEMILIM; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1260.10; -; 1.
DR HAMAP; MF_00389; Thiourid_synth_C; 1.
DR InterPro; IPR027396; DsrEFH-like.
DR InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR InterPro; IPR037450; Sulphur_relay_TusC.
DR InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR PANTHER; PTHR38780; PTHR38780; 1.
DR Pfam; PF02635; DrsE; 1.
DR SUPFAM; SSF75169; SSF75169; 1.
DR TIGRFAMs; TIGR03010; sulf_tusC_dsrF; 1.
PE 3: Inferred from homology;
KW Cytoplasm; tRNA processing.
FT CHAIN 1..121
FT /note="Protein TusC"
FT /id="PRO_0000234461"
SQ SEQUENCE 121 AA; 13435 MW; 31A843FDF73E2493 CRC64;
MARKRIAFIF TQGPHGSSAG REGLDALLAT SALSEDIGVF FISDGVLQLL PQQQPEKILA
RNYIATFGVL PLYDVENCYL CERSLQQRGL SKMADWILDV TVLSPADLRR ELGTYDVVLT
F