C560_PIG
ID C560_PIG Reviewed; 169 AA.
AC D0VWV4;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Succinate dehydrogenase cytochrome b560 subunit, mitochondrial;
DE AltName: Full=Succinate-ubiquinone oxidoreductase cytochrome B large subunit;
DE Short=CYBL;
DE Flags: Precursor;
GN Name=SDHC;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=17480203; DOI=10.1111/j.1742-4658.2007.05698.x;
RA Huo X., Su D., Wang A., Zhai Y., Xu J., Li X., Bartlam M., Sun F., Rao Z.;
RT "Preliminary molecular characterization and crystallization of
RT mitochondrial respiratory complex II from porcine heart.";
RL FEBS J. 274:1524-1529(2007).
RN [2] {ECO:0007744|PDB:1ZOY, ECO:0007744|PDB:1ZP0}
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 30-169 IN COMPLEXES WITH HEME,
RP SUBUNIT, AND MEMBRANE TOPOLOGY.
RX PubMed=15989954; DOI=10.1016/j.cell.2005.05.025;
RA Sun F., Huo X., Zhai Y., Wang A., Xu J., Su D., Bartlam M., Rao Z.;
RT "Crystal structure of mitochondrial respiratory membrane protein complex
RT II.";
RL Cell 121:1043-1057(2005).
CC -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH)
CC that is involved in complex II of the mitochondrial electron transport
CC chain and is responsible for transferring electrons from succinate to
CC ubiquinone (coenzyme Q). {ECO:0000269|PubMed:17480203}.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000269|PubMed:15989954};
CC Note=The heme b is bound between the two transmembrane subunits SDHC
CC and SDHD. {ECO:0000269|PubMed:15989954};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC -!- SUBUNIT: Component of complex II composed of four subunits: the
CC flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome
CC b560 composed of SDHC and SDHD. {ECO:0000269|PubMed:15989954}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:17480203}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17480203}.
CC -!- TISSUE SPECIFICITY: Detected in heart muscle (at protein level).
CC {ECO:0000269|PubMed:17480203}.
CC -!- SIMILARITY: Belongs to the cytochrome b560 family. {ECO:0000305}.
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DR RefSeq; XP_003125707.2; XM_003125659.5.
DR PDB; 1ZOY; X-ray; 2.40 A; C=30-169.
DR PDB; 1ZP0; X-ray; 3.50 A; C=30-169.
DR PDB; 3ABV; X-ray; 3.24 A; C=30-169.
DR PDB; 3AE1; X-ray; 3.14 A; C=30-169.
DR PDB; 3AE2; X-ray; 3.10 A; C=30-169.
DR PDB; 3AE3; X-ray; 3.35 A; C=30-169.
DR PDB; 3AE4; X-ray; 2.91 A; C=30-169.
DR PDB; 3AE5; X-ray; 3.41 A; C=30-169.
DR PDB; 3AE6; X-ray; 3.40 A; C=30-169.
DR PDB; 3AE7; X-ray; 3.62 A; C=30-169.
DR PDB; 3AE8; X-ray; 3.40 A; C=30-169.
DR PDB; 3AE9; X-ray; 3.31 A; C=30-169.
DR PDB; 3AEA; X-ray; 3.39 A; C=30-169.
DR PDB; 3AEB; X-ray; 3.00 A; C=30-169.
DR PDB; 3AEC; X-ray; 3.61 A; C=30-169.
DR PDB; 3AED; X-ray; 3.52 A; C=30-169.
DR PDB; 3AEE; X-ray; 3.22 A; C=30-169.
DR PDB; 3AEF; X-ray; 2.80 A; C=30-169.
DR PDB; 3AEG; X-ray; 3.27 A; C=30-169.
DR PDB; 3SFD; X-ray; 2.61 A; C=30-169.
DR PDB; 3SFE; X-ray; 2.81 A; C=30-169.
DR PDB; 4YTP; X-ray; 3.10 A; C=1-169.
DR PDB; 4YXD; X-ray; 3.00 A; C=1-169.
DR PDBsum; 1ZOY; -.
DR PDBsum; 1ZP0; -.
DR PDBsum; 3ABV; -.
DR PDBsum; 3AE1; -.
DR PDBsum; 3AE2; -.
DR PDBsum; 3AE3; -.
DR PDBsum; 3AE4; -.
DR PDBsum; 3AE5; -.
DR PDBsum; 3AE6; -.
DR PDBsum; 3AE7; -.
DR PDBsum; 3AE8; -.
DR PDBsum; 3AE9; -.
DR PDBsum; 3AEA; -.
DR PDBsum; 3AEB; -.
DR PDBsum; 3AEC; -.
DR PDBsum; 3AED; -.
DR PDBsum; 3AEE; -.
DR PDBsum; 3AEF; -.
DR PDBsum; 3AEG; -.
DR PDBsum; 3SFD; -.
DR PDBsum; 3SFE; -.
DR PDBsum; 4YTP; -.
DR PDBsum; 4YXD; -.
DR AlphaFoldDB; D0VWV4; -.
DR SMR; D0VWV4; -.
DR STRING; 9823.ENSSSCP00000027481; -.
DR BindingDB; D0VWV4; -.
DR ChEMBL; CHEMBL2366564; -.
DR PaxDb; D0VWV4; -.
DR PeptideAtlas; D0VWV4; -.
DR PRIDE; D0VWV4; -.
DR Ensembl; ENSSSCT00000045783; ENSSSCP00000053659; ENSSSCG00000030318.
DR Ensembl; ENSSSCT00015011874; ENSSSCP00015004688; ENSSSCG00015008931.
DR Ensembl; ENSSSCT00025006739; ENSSSCP00025002788; ENSSSCG00025004969.
DR Ensembl; ENSSSCT00030039217; ENSSSCP00030018057; ENSSSCG00030028035.
DR Ensembl; ENSSSCT00035098999; ENSSSCP00035041870; ENSSSCG00035073083.
DR Ensembl; ENSSSCT00040078450; ENSSSCP00040033836; ENSSSCG00040057801.
DR Ensembl; ENSSSCT00045057057; ENSSSCP00045039867; ENSSSCG00045033311.
DR Ensembl; ENSSSCT00050043755; ENSSSCP00050018047; ENSSSCG00050032579.
DR Ensembl; ENSSSCT00055004386; ENSSSCP00055003368; ENSSSCG00055002313.
DR Ensembl; ENSSSCT00060069080; ENSSSCP00060029719; ENSSSCG00060050777.
DR Ensembl; ENSSSCT00065037789; ENSSSCP00065015918; ENSSSCG00065028024.
DR Ensembl; ENSSSCT00070050221; ENSSSCP00070042436; ENSSSCG00070025122.
DR GeneID; 100524676; -.
DR KEGG; ssc:100524676; -.
DR CTD; 6391; -.
DR VGNC; VGNC:98852; SDHC.
DR eggNOG; KOG0449; Eukaryota.
DR GeneTree; ENSGT00390000000566; -.
DR HOGENOM; CLU_094691_1_1_1; -.
DR InParanoid; D0VWV4; -.
DR OMA; IPGGIPC; -.
DR OrthoDB; 1443173at2759; -.
DR TreeFam; TF313317; -.
DR UniPathway; UPA00223; -.
DR EvolutionaryTrace; D0VWV4; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Proteomes; UP000314985; Chromosome 4.
DR Bgee; ENSSSCG00000030318; Expressed in metanephros cortex and 45 other tissues.
DR ExpressionAtlas; D0VWV4; baseline and differential.
DR Genevisible; D0VWV4; SS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); IDA:UniProtKB.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000104; F:succinate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1300.10; -; 1.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR InterPro; IPR018495; Succ_DH_cyt_bsu_CS.
DR InterPro; IPR014314; Succ_DH_cytb556.
DR InterPro; IPR000701; SuccDH_FuR_B_TM-su.
DR PANTHER; PTHR10978; PTHR10978; 1.
DR Pfam; PF01127; Sdh_cyt; 1.
DR SUPFAM; SSF81343; SSF81343; 1.
DR TIGRFAMs; TIGR02970; succ_dehyd_cytB; 1.
DR PROSITE; PS01000; SDH_CYT_1; 1.
DR PROSITE; PS01001; SDH_CYT_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport;
KW Tricarboxylic acid cycle.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 30..169
FT /note="Succinate dehydrogenase cytochrome b560 subunit,
FT mitochondrial"
FT /id="PRO_0000391750"
FT TOPO_DOM 30..62
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 63..92
FT /note="Helical"
FT TOPO_DOM 93..112
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 113..137
FT /note="Helical"
FT TOPO_DOM 138..144
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 145..166
FT /note="Helical"
FT TOPO_DOM 167..169
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT BINDING 127
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_note="ligand shared with SDHD"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000269|PubMed:15989954,
FT ECO:0007744|PDB:1ZOY, ECO:0007744|PDB:1ZP0"
FT HELIX 34..46
FT /evidence="ECO:0007829|PDB:1ZOY"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:3AEA"
FT TURN 56..58
FT /evidence="ECO:0007829|PDB:1ZOY"
FT HELIX 63..91
FT /evidence="ECO:0007829|PDB:1ZOY"
FT STRAND 92..94
FT /evidence="ECO:0007829|PDB:3AEF"
FT HELIX 96..104
FT /evidence="ECO:0007829|PDB:1ZOY"
FT TURN 105..107
FT /evidence="ECO:0007829|PDB:1ZOY"
FT HELIX 110..138
FT /evidence="ECO:0007829|PDB:1ZOY"
FT TURN 139..142
FT /evidence="ECO:0007829|PDB:3SFD"
FT HELIX 145..166
FT /evidence="ECO:0007829|PDB:1ZOY"
SQ SEQUENCE 169 AA; 18518 MW; 42EB611C1DCDF0A5 CRC64;
MAALLLRHVG RHCLRAHLSP QLCIRNAVPL GTTAKEEMER FWNKNLGSNR PLSPHITIYR
WSLPMAMSIC HRGTGIALSA GVSLFGLSAL LLPGNFESHL ELVKSLCLGP TLIYTAKFGI
VFPLMYHTWN GIRHLIWDLG KGLTIPQLTQ SGVVVLILTV LSSVGLAAM
