TUS_ECO24
ID TUS_ECO24 Reviewed; 309 AA.
AC A7ZM70;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN Name=tus {ECO:0000255|HAMAP-Rule:MF_00483};
GN OrderedLocusNames=EcE24377A_1819;
OS Escherichia coli O139:H28 (strain E24377A / ETEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331111;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E24377A / ETEC;
RX PubMed=18676672; DOI=10.1128/jb.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Trans-acting protein required for termination of DNA
CC replication. Binds to DNA replication terminator sequences (terA to
CC terF) to prevent the passage of replication forks. The termination
CC efficiency will be affected by the affinity of this protein for the
CC terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC Rule:MF_00483}.
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DR EMBL; CP000800; ABV21189.1; -; Genomic_DNA.
DR RefSeq; WP_000135186.1; NC_009801.1.
DR AlphaFoldDB; A7ZM70; -.
DR SMR; A7ZM70; -.
DR EnsemblBacteria; ABV21189; ABV21189; EcE24377A_1819.
DR GeneID; 66674499; -.
DR KEGG; ecw:EcE24377A_1819; -.
DR HOGENOM; CLU_078181_0_0_6; -.
DR OMA; QVQYACP; -.
DR Proteomes; UP000001122; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.14.10; -; 1.
DR HAMAP; MF_00483; Rep_term_Tus; 1.
DR InterPro; IPR008865; DNA_replication_term_site-bd.
DR InterPro; IPR036381; Tus_dom1.
DR InterPro; IPR036384; Tus_sf.
DR Pfam; PF05472; Ter; 1.
DR SUPFAM; SSF56596; SSF56596; 1.
DR TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA replication; DNA-binding.
FT CHAIN 1..309
FT /note="DNA replication terminus site-binding protein"
FT /id="PRO_1000060425"
SQ SEQUENCE 309 AA; 35771 MW; 69C06529A8D4EFDC CRC64;
MARYDLVDRL NTTFRQMEQE LATFAAHLEQ HKLLVARVFS LPEVKKEDEH NPLNRIEVKQ
HLGNDAQSLA LRHFRHLFIQ QQSENRSSKA AVRLPGVLCY QVDNLSQAAL VSHIQHINKL
KTTFEHIVTV ESELPTAARF EWVHRHLPGL ITLNAYRTLT VLHDPATLRF GWANKHIIKN
LHRDEVLAQL EKSLKSPRSV APWTREEWQR KLEREYQDIA ALPQNAKLKI KRPVKVQPIA
RVWYKGDQKQ VQHACPTPLI ALINRDNGAG VPDVGELLNY DADNVQHRYK PQAQPLRLII
PRLHLYVAD