ID   TUS_ECOL6               Reviewed;         309 AA.
AC   Q8FHA8;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE            Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN   Name=tus {ECO:0000255|HAMAP-Rule:MF_00483}; OrderedLocusNames=c2002;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Trans-acting protein required for termination of DNA
CC       replication. Binds to DNA replication terminator sequences (terA to
CC       terF) to prevent the passage of replication forks. The termination
CC       efficiency will be affected by the affinity of this protein for the
CC       terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC       Rule:MF_00483}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN80462.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN80462.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001327661.1; NC_004431.1.
DR   AlphaFoldDB; Q8FHA8; -.
DR   SMR; Q8FHA8; -.
DR   STRING; 199310.c2002; -.
DR   EnsemblBacteria; AAN80462; AAN80462; c2002.
DR   KEGG; ecc:c2002; -.
DR   eggNOG; ENOG502Z895; Bacteria.
DR   HOGENOM; CLU_078181_0_0_6; -.
DR   OMA; QVQYACP; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.14.10; -; 1.
DR   HAMAP; MF_00483; Rep_term_Tus; 1.
DR   InterPro; IPR008865; DNA_replication_term_site-bd.
DR   InterPro; IPR036381; Tus_dom1.
DR   InterPro; IPR036384; Tus_sf.
DR   Pfam; PF05472; Ter; 1.
DR   SUPFAM; SSF56596; SSF56596; 1.
DR   TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-binding.
FT   CHAIN           1..309
FT                   /note="DNA replication terminus site-binding protein"
FT                   /id="PRO_0000049414"
SQ   SEQUENCE   309 AA;  35753 MW;  E18E78E9EFF8C94D CRC64;
     MARYDLVDRL NTTFRQMEQE LAAFAAELEQ HKLLVARVFS LPEVKKEDEH NPLNRIEVKQ
     HLGNDAQSLA LRHFRHLFIQ QQSENRSSKA AVRLPGVLCY QVDNFSQAAL VSHIQHINKL
     KTTFEHIVTV ESELPSAARF EWVHRHLPGL ITLNAYRTLT VLHDPATLRF GWANKHIIKN
     LHRDEVLAQL EKSLKSPRSV APWTREEWQR KLEREYQDIA ALPQNAKLKI KRPVKVQPIA
     RVWYKGDQKQ VQHACPTPLI ALINRDNGAG VPDVGELLNY DADNVQHRYK PQAQPLRLII
     PRLHLYVAD