ID   TUS_KLEP7               Reviewed;         310 AA.
AC   A6T8M8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE            Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN   Name=tus {ECO:0000255|HAMAP-Rule:MF_00483};
GN   OrderedLocusNames=KPN78578_14880; ORFNames=KPN_01518;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Trans-acting protein required for termination of DNA
CC       replication. Binds to DNA replication terminator sequences (terA to
CC       terF) to prevent the passage of replication forks. The termination
CC       efficiency will be affected by the affinity of this protein for the
CC       terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC       Rule:MF_00483}.
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DR   EMBL; CP000647; ABR76949.1; -; Genomic_DNA.
DR   RefSeq; WP_015958355.1; NC_009648.1.
DR   AlphaFoldDB; A6T8M8; -.
DR   SMR; A6T8M8; -.
DR   STRING; 272620.KPN_01518; -.
DR   EnsemblBacteria; ABR76949; ABR76949; KPN_01518.
DR   KEGG; kpn:KPN_01518; -.
DR   HOGENOM; CLU_078181_0_0_6; -.
DR   OMA; QVQYACP; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.14.10; -; 1.
DR   HAMAP; MF_00483; Rep_term_Tus; 1.
DR   InterPro; IPR008865; DNA_replication_term_site-bd.
DR   InterPro; IPR036381; Tus_dom1.
DR   InterPro; IPR036384; Tus_sf.
DR   Pfam; PF05472; Ter; 1.
DR   SUPFAM; SSF56596; SSF56596; 1.
DR   TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..310
FT                   /note="DNA replication terminus site-binding protein"
FT                   /id="PRO_1000014332"
SQ   SEQUENCE   310 AA;  35260 MW;  219D5A3426F6CE72 CRC64;
     MASYDLVERL NNTFRQIELE LQALQQALSD CRLLAGRVFE LPAIGKDAEH DPLATIPVVQ
     HIGKTALARA LRHYSHLFIQ QQSENRSSKA AVRLPGAICL QVTAAEQQDL LARIQHINAL
     KATFEKIVTV DSGLPPTARF EWVHRHLPGL ITLSAYRTLT PLVDPSTIRF GWANKHVIKN
     LTRDQVLMML EKSLQAPRAV PPWTREQWQS KLEREYQDIA ALPQRARLKI KRPVKVQPIA
     RVWYAGEQKQ VQYACPSPLI ALMSGSREVS VPDIGELLNY DADNVQYRYK PEAQSLRLLI
     PRLHLWLASE