ID   TUS_KLEPO               Reviewed;         310 AA.
AC   O52715;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE            Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN   Name=tus {ECO:0000255|HAMAP-Rule:MF_00483};
OS   Klebsiella pneumoniae subsp. ozaenae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=574;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11523786; DOI=10.1007/s004380100501;
RA   Henderson T.A., Nilles A.F., Valjavec-Gratian M., Hill T.M.;
RT   "Site-directed mutagenesis and phylogenetic comparisons of the Escherichia
RT   coli Tus protein: DNA-protein interactions alone cannot account for Tus
RT   activity.";
RL   Mol. Genet. Genomics 265:941-953(2001).
CC   -!- FUNCTION: Trans-acting protein required for termination of DNA
CC       replication. Binds to DNA replication terminator sequences (terA to
CC       terF) to prevent the passage of replication forks. The termination
CC       efficiency will be affected by the affinity of this protein for the
CC       terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC       Rule:MF_00483}.
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DR   EMBL; AF045243; AAC02705.2; -; Genomic_DNA.
DR   RefSeq; WP_004148259.1; NZ_NWFA01000002.1.
DR   AlphaFoldDB; O52715; -.
DR   SMR; O52715; -.
DR   STRING; 1218098.GCA_001598715_02559; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.14.10; -; 1.
DR   HAMAP; MF_00483; Rep_term_Tus; 1.
DR   InterPro; IPR008865; DNA_replication_term_site-bd.
DR   InterPro; IPR036381; Tus_dom1.
DR   InterPro; IPR036384; Tus_sf.
DR   Pfam; PF05472; Ter; 1.
DR   SUPFAM; SSF56596; SSF56596; 1.
DR   TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-binding.
FT   CHAIN           1..310
FT                   /note="DNA replication terminus site-binding protein"
FT                   /id="PRO_0000049416"
SQ   SEQUENCE   310 AA;  35188 MW;  219D5896ACDCCE72 CRC64;
     MASYDLVERL NNTFRQIELE LQALQQALSD CRLLAGRVFE LPAIGKDAEH DPLATIPVVQ
     HIGKTALARA LRHYSHLFIQ QQSENRSSKA AVRLPGAICL QVTAAEQQDL LARIQHINAL
     KATFEKIVTV DSGLPPTARF EWVHRHLPGL ITLSAYRTLT PLVDPSTIRF GWANKHVIKN
     LTRDQVLMML EKSLQAPRAV PPWTREQWQS KLEREYQDIA ALPQRARLKI KRPVKVQPIA
     RVWYAGEQKQ VQYACPSPLI ALMSGSRGVS VPDIGELLNY DADNVQYRYK PEAQSLRLLI
     PRLHLWLASE