TUS_SALTY
ID TUS_SALTY Reviewed; 309 AA.
AC O52714;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN Name=tus {ECO:0000255|HAMAP-Rule:MF_00483}; OrderedLocusNames=STM1470;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=11523786; DOI=10.1007/s004380100501;
RA Henderson T.A., Nilles A.F., Valjavec-Gratian M., Hill T.M.;
RT "Site-directed mutagenesis and phylogenetic comparisons of the Escherichia
RT coli Tus protein: DNA-protein interactions alone cannot account for Tus
RT activity.";
RL Mol. Genet. Genomics 265:941-953(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Trans-acting protein required for termination of DNA
CC replication. Binds to DNA replication terminator sequences (terA to
CC terF) to prevent the passage of replication forks. The termination
CC efficiency will be affected by the affinity of this protein for the
CC terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC Rule:MF_00483}.
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DR EMBL; AF045242; AAC02704.2; -; Genomic_DNA.
DR EMBL; AE006468; AAL20390.1; -; Genomic_DNA.
DR RefSeq; NP_460431.1; NC_003197.2.
DR RefSeq; WP_000092490.1; NC_003197.2.
DR AlphaFoldDB; O52714; -.
DR SMR; O52714; -.
DR STRING; 99287.STM1470; -.
DR PaxDb; O52714; -.
DR EnsemblBacteria; AAL20390; AAL20390; STM1470.
DR GeneID; 1252988; -.
DR KEGG; stm:STM1470; -.
DR PATRIC; fig|99287.12.peg.1552; -.
DR HOGENOM; CLU_078181_0_0_6; -.
DR OMA; QVQYACP; -.
DR PhylomeDB; O52714; -.
DR BioCyc; SENT99287:STM1470-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.14.10; -; 1.
DR HAMAP; MF_00483; Rep_term_Tus; 1.
DR InterPro; IPR008865; DNA_replication_term_site-bd.
DR InterPro; IPR036381; Tus_dom1.
DR InterPro; IPR036384; Tus_sf.
DR Pfam; PF05472; Ter; 1.
DR SUPFAM; SSF56596; SSF56596; 1.
DR TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA replication; DNA-binding; Reference proteome.
FT CHAIN 1..309
FT /note="DNA replication terminus site-binding protein"
FT /id="PRO_0000049420"
SQ SEQUENCE 309 AA; 35487 MW; BA0A62D4291A8B78 CRC64;
MSRYDLVERL NGTFRQIEQH LAALTDNLQQ HSLLIARVFS LPQVTKEAEH APLDTIEVTQ
HLGKEAEALA LRHYRHLFIQ QQSENRSSKA AVRLPGVLCY QVDNATQLDL ENQIQRINQL
KTTFEQMVTV ESGLPSAARF EWVHRHLPGL ITLNAYRTLT LINNPATIRF GWANKHIIKN
LSRDEVLSQL KKSLASPRSV PPWTREQWQF KLEREYQDIA ALPQQARLKI KRPVKVQPIS
RIWYKGQQKQ VQHACPTPII ALINTDNGAG VPDIGGLENY DADNIQHRFK PQAQPLRLII
PRLHLYVAD
