ID   TUS_YERPE               Reviewed;         311 AA.
AC   Q9L6X9; Q0WEQ6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
DE            Short=Ter-binding protein {ECO:0000255|HAMAP-Rule:MF_00483};
GN   Name=tus {ECO:0000255|HAMAP-Rule:MF_00483};
GN   OrderedLocusNames=YPO2265, y2107, YP_2062;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11523786; DOI=10.1007/s004380100501;
RA   Henderson T.A., Nilles A.F., Valjavec-Gratian M., Hill T.M.;
RT   "Site-directed mutagenesis and phylogenetic comparisons of the Escherichia
RT   coli Tus protein: DNA-protein interactions alone cannot account for Tus
RT   activity.";
RL   Mol. Genet. Genomics 265:941-953(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Trans-acting protein required for termination of DNA
CC       replication. Binds to DNA replication terminator sequences (terA to
CC       terF) to prevent the passage of replication forks. The termination
CC       efficiency will be affected by the affinity of this protein for the
CC       terminator sequence. {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00483}.
CC   -!- SIMILARITY: Belongs to the Tus family. {ECO:0000255|HAMAP-
CC       Rule:MF_00483}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM85670.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS62275.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF231032; AAF68950.1; -; Genomic_DNA.
DR   EMBL; AL590842; CAL20892.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85670.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62275.1; ALT_INIT; Genomic_DNA.
DR   PIR; AI0275; AI0275.
DR   RefSeq; YP_002347232.1; NC_003143.1.
DR   AlphaFoldDB; Q9L6X9; -.
DR   SMR; Q9L6X9; -.
DR   STRING; 214092.YPO2265; -.
DR   PaxDb; Q9L6X9; -.
DR   DNASU; 1147054; -.
DR   EnsemblBacteria; AAM85670; AAM85670; y2107.
DR   EnsemblBacteria; AAS62275; AAS62275; YP_2062.
DR   KEGG; ype:YPO2265; -.
DR   KEGG; ypj:CH55_355; -.
DR   KEGG; ypk:y2107; -.
DR   KEGG; ypl:CH46_2849; -.
DR   KEGG; ypm:YP_2062; -.
DR   KEGG; ypv:BZ15_1276; -.
DR   KEGG; ypw:CH59_3852; -.
DR   PATRIC; fig|214092.21.peg.2661; -.
DR   eggNOG; ENOG502Z895; Bacteria.
DR   HOGENOM; CLU_078181_0_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.14.10; -; 1.
DR   HAMAP; MF_00483; Rep_term_Tus; 1.
DR   InterPro; IPR008865; DNA_replication_term_site-bd.
DR   InterPro; IPR036381; Tus_dom1.
DR   InterPro; IPR036384; Tus_sf.
DR   Pfam; PF05472; Ter; 1.
DR   SUPFAM; SSF56596; SSF56596; 1.
DR   TIGRFAMs; TIGR02648; rep_term_tus; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-binding; Reference proteome.
FT   CHAIN           1..311
FT                   /note="DNA replication terminus site-binding protein"
FT                   /id="PRO_0000049424"
SQ   SEQUENCE   311 AA;  36180 MW;  24D41BC78918E0DC CRC64;
     MNKYDLIERM NTRFAELEVT LHQLHQQLDD LPLIAARVFS LPEIEKGTEH QPIEQITVNI
     TEGEHAKKLG LQHFQRLFLH HQGQHVSSKA ALRLPGVLCF SVTDKELIEC QDIIKKTNQL
     KAELEHIITV ESGLPSEQRF EFVHTHLHGL ITLNTYRTIT PLINPSSVRF GWANKHIIKN
     VTREDILLQL EKSLNAGRAV PPFTREQWRE LISLEINDVQ RLPEKTRLKI KRPVKVQPIA
     RVWYQEQQKQ VQHPCPMPLI AFCQHQLGAE LPKLGELTDY DVKHIKHKYK PDAKPLRLLV
     PRLHLYVELE P