TV23A_HUMAN
ID TV23A_HUMAN Reviewed; 213 AA.
AC A6NH52; B2RUV4; B7ZW18;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Golgi apparatus membrane protein TVP23 homolog A;
GN Name=TVP23A; Synonyms=FAM18A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A6NH52; O95214: LEPROTL1; NbExp=3; IntAct=EBI-13296313, EBI-750776;
CC A6NH52; P57086: SCAND1; NbExp=3; IntAct=EBI-13296313, EBI-745846;
CC A6NH52; Q8TF74: WIPF2; NbExp=3; IntAct=EBI-13296313, EBI-2850112;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NH52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NH52-2; Sequence=VSP_054190;
CC -!- SIMILARITY: Belongs to the TVP23 family. {ECO:0000305}.
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DR EMBL; AK294418; BAG57667.1; -; mRNA.
DR EMBL; AC074136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146882; AAI46883.1; -; mRNA.
DR EMBL; BC146886; AAI46887.1; -; mRNA.
DR EMBL; BC171817; AAI71817.1; -; mRNA.
DR CCDS; CCDS45408.1; -. [A6NH52-1]
DR RefSeq; NP_001072980.1; NM_001079512.3. [A6NH52-1]
DR RefSeq; XP_006721007.1; XM_006720944.3. [A6NH52-1]
DR RefSeq; XP_011520956.1; XM_011522654.2. [A6NH52-1]
DR RefSeq; XP_016879138.1; XM_017023649.1. [A6NH52-1]
DR AlphaFoldDB; A6NH52; -.
DR BioGRID; 612864; 8.
DR IntAct; A6NH52; 3.
DR STRING; 9606.ENSP00000299866; -.
DR iPTMnet; A6NH52; -.
DR PhosphoSitePlus; A6NH52; -.
DR BioMuta; TVP23A; -.
DR PaxDb; A6NH52; -.
DR PeptideAtlas; A6NH52; -.
DR PRIDE; A6NH52; -.
DR ProteomicsDB; 1180; -. [A6NH52-1]
DR Antibodypedia; 71684; 26 antibodies from 6 providers.
DR DNASU; 780776; -.
DR Ensembl; ENST00000299866.13; ENSP00000299866.8; ENSG00000166676.17. [A6NH52-1]
DR Ensembl; ENST00000456096.6; ENSP00000411972.2; ENSG00000166676.17. [A6NH52-2]
DR Ensembl; ENST00000575135.5; ENSP00000460567.1; ENSG00000166676.17. [A6NH52-1]
DR GeneID; 780776; -.
DR KEGG; hsa:780776; -.
DR MANE-Select; ENST00000299866.13; ENSP00000299866.8; NM_001079512.4; NP_001072980.1.
DR UCSC; uc010buo.2; human. [A6NH52-1]
DR CTD; 780776; -.
DR DisGeNET; 780776; -.
DR GeneCards; TVP23A; -.
DR HGNC; HGNC:20398; TVP23A.
DR HPA; ENSG00000166676; Tissue enhanced (brain).
DR neXtProt; NX_A6NH52; -.
DR OpenTargets; ENSG00000166676; -.
DR PharmGKB; PA134902394; -.
DR VEuPathDB; HostDB:ENSG00000166676; -.
DR eggNOG; KOG3195; Eukaryota.
DR GeneTree; ENSGT00390000004428; -.
DR HOGENOM; CLU_074845_3_0_1; -.
DR InParanoid; A6NH52; -.
DR OMA; ICPVIWI; -.
DR OrthoDB; 1356321at2759; -.
DR PhylomeDB; A6NH52; -.
DR TreeFam; TF312906; -.
DR PathwayCommons; A6NH52; -.
DR SignaLink; A6NH52; -.
DR BioGRID-ORCS; 780776; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; TVP23A; human.
DR GenomeRNAi; 780776; -.
DR Pharos; A6NH52; Tdark.
DR PRO; PR:A6NH52; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A6NH52; protein.
DR Bgee; ENSG00000166676; Expressed in colonic epithelium and 99 other tissues.
DR ExpressionAtlas; A6NH52; baseline and differential.
DR Genevisible; A6NH52; HS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR008564; TVP23-like.
DR PANTHER; PTHR13019; PTHR13019; 1.
DR Pfam; PF05832; DUF846; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..213
FT /note="Golgi apparatus membrane protein TVP23 homolog A"
FT /id="PRO_0000327940"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 31..77
FT /note="HPLATFFHLFFRVSAIVTYVSCDWFSKSFVGCFVMVLLLLSLDFWSV -> D
FT RVSKLLASVILLPWPPKVLGL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054190"
SQ SEQUENCE 213 AA; 24111 MW; 8D1FA2FB470452B2 CRC64;
MKQALVDDTE DVSLDFGNEE ELAFRKAKIR HPLATFFHLF FRVSAIVTYV SCDWFSKSFV
GCFVMVLLLL SLDFWSVKNV TGRLLVGLRW WNQIDEDGKS HWIFEARKVS PNSIAATEAE
ARIFWLGLII CPMIWIVFFF STLFSLKLKW LALVVAGISL QAANLYGYIL CKMGGNSDIG
KVTASFLSQT VFQTACPGDF QKPGLEGLEI HQH
