TV23B_HUMAN
ID TV23B_HUMAN Reviewed; 205 AA.
AC Q9NYZ1; A8K448; Q96HK5; Q9Y3E6;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Golgi apparatus membrane protein TVP23 homolog B;
GN Name=TVP23B; Synonyms=FAM18B, FAM18B1; ORFNames=CGI-148, NPD008;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-55.
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLU-55.
RC TISSUE=Pituitary;
RA Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.;
RT "A novel gene expressed in normal human pituitary.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-55.
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-55.
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- INTERACTION:
CC Q9NYZ1; Q9BV23: ABHD6; NbExp=3; IntAct=EBI-11343401, EBI-3916106;
CC Q9NYZ1; Q96LK0: CEP19; NbExp=3; IntAct=EBI-11343401, EBI-741885;
CC Q9NYZ1; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-11343401, EBI-1052304;
CC Q9NYZ1; Q96AL5: PBX3; NbExp=3; IntAct=EBI-11343401, EBI-741171;
CC Q9NYZ1; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-11343401, EBI-7545592;
CC Q9NYZ1; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-11343401, EBI-17247926;
CC Q9NYZ1; Q8N114-3: SHISA5; NbExp=3; IntAct=EBI-11343401, EBI-13369834;
CC Q9NYZ1; Q14973: SLC10A1; NbExp=3; IntAct=EBI-11343401, EBI-3923031;
CC Q9NYZ1; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-11343401, EBI-18159983;
CC Q9NYZ1; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-11343401, EBI-17295964;
CC Q9NYZ1; Q17RD7: SYT16; NbExp=3; IntAct=EBI-11343401, EBI-10238936;
CC Q9NYZ1; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-11343401, EBI-6268651;
CC Q9NYZ1; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-11343401, EBI-12947623;
CC Q9NYZ1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-11343401, EBI-8638294;
CC Q9NYZ1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-11343401, EBI-11742770;
CC Q9NYZ1; Q9Y320: TMX2; NbExp=3; IntAct=EBI-11343401, EBI-6447886;
CC Q9NYZ1; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-11343401, EBI-7850136;
CC Q9NYZ1; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-11343401, EBI-751204;
CC Q9NYZ1; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-11343401, EBI-751253;
CC Q9NYZ1; Q96EC8: YIPF6; NbExp=6; IntAct=EBI-11343401, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TVP23 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD34143.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF151906; AAD34143.1; ALT_FRAME; mRNA.
DR EMBL; AF223467; AAF64142.1; -; mRNA.
DR EMBL; BX537929; CAD97906.1; -; mRNA.
DR EMBL; AK290813; BAF83502.1; -; mRNA.
DR EMBL; AC107982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008430; AAH08430.1; -; mRNA.
DR CCDS; CCDS42274.1; -.
DR RefSeq; NP_001303848.1; NM_001316919.1.
DR RefSeq; NP_001303849.1; NM_001316920.1.
DR RefSeq; NP_001303850.1; NM_001316921.1.
DR RefSeq; NP_001303851.1; NM_001316922.1.
DR RefSeq; NP_001303852.1; NM_001316923.1.
DR RefSeq; NP_001303853.1; NM_001316924.1.
DR RefSeq; NP_057162.4; NM_016078.5.
DR AlphaFoldDB; Q9NYZ1; -.
DR BioGRID; 119236; 29.
DR IntAct; Q9NYZ1; 27.
DR STRING; 9606.ENSP00000305654; -.
DR iPTMnet; Q9NYZ1; -.
DR PhosphoSitePlus; Q9NYZ1; -.
DR BioMuta; TVP23B; -.
DR DMDM; 296434501; -.
DR jPOST; Q9NYZ1; -.
DR MassIVE; Q9NYZ1; -.
DR MaxQB; Q9NYZ1; -.
DR PaxDb; Q9NYZ1; -.
DR PeptideAtlas; Q9NYZ1; -.
DR PRIDE; Q9NYZ1; -.
DR Antibodypedia; 6796; 31 antibodies from 15 providers.
DR DNASU; 51030; -.
DR Ensembl; ENST00000307767.13; ENSP00000305654.8; ENSG00000171928.14.
DR GeneID; 51030; -.
DR KEGG; hsa:51030; -.
DR MANE-Select; ENST00000307767.13; ENSP00000305654.8; NM_016078.6; NP_057162.4.
DR UCSC; uc002gum.3; human.
DR CTD; 51030; -.
DR DisGeNET; 51030; -.
DR GeneCards; TVP23B; -.
DR HGNC; HGNC:20399; TVP23B.
DR HPA; ENSG00000171928; Low tissue specificity.
DR neXtProt; NX_Q9NYZ1; -.
DR OpenTargets; ENSG00000171928; -.
DR PharmGKB; PA134871046; -.
DR VEuPathDB; HostDB:ENSG00000171928; -.
DR eggNOG; KOG3195; Eukaryota.
DR GeneTree; ENSGT00390000004428; -.
DR InParanoid; Q9NYZ1; -.
DR OMA; DGNNHWK; -.
DR OrthoDB; 1356321at2759; -.
DR PhylomeDB; Q9NYZ1; -.
DR TreeFam; TF312906; -.
DR PathwayCommons; Q9NYZ1; -.
DR SignaLink; Q9NYZ1; -.
DR BioGRID-ORCS; 51030; 9 hits in 995 CRISPR screens.
DR ChiTaRS; TVP23B; human.
DR GeneWiki; FAM18B1; -.
DR GenomeRNAi; 51030; -.
DR Pharos; Q9NYZ1; Tdark.
DR PRO; PR:Q9NYZ1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9NYZ1; protein.
DR Bgee; ENSG00000171928; Expressed in islet of Langerhans and 104 other tissues.
DR ExpressionAtlas; Q9NYZ1; baseline and differential.
DR Genevisible; Q9NYZ1; HS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR008564; TVP23-like.
DR PANTHER; PTHR13019; PTHR13019; 1.
DR Pfam; PF05832; DUF846; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..205
FT /note="Golgi apparatus membrane protein TVP23 homolog B"
FT /id="PRO_0000212828"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT VARIANT 55
FT /note="G -> E (in dbSNP:rs61075345)"
FT /evidence="ECO:0000269|PubMed:10810093,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.2"
FT /id="VAR_060476"
FT CONFLICT 48
FT /note="I -> T (in Ref. 4; BAF83502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 205 AA; 23576 MW; E221C320822187FC CRC64;
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV YLLCGLLSSS
FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG KSHWVFESRK ESSQENKTVS
EAESRIFWLG LIACPVLWVI FAFSALFSFR VKWLAVVIMG VVLQGANLYG YIRCKVRSRK
HLTSMATSYF GKQFLRQNTG DDQTS
