TV23B_MOUSE
ID TV23B_MOUSE Reviewed; 205 AA.
AC Q9D8T4; Q3UBJ3;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Golgi apparatus membrane protein TVP23 homolog B;
GN Name=Tvp23b; Synonyms=Fam18b, Fam18b1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow macrophage, Liver, Ovary, Pancreas, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TVP23 family. {ECO:0000305}.
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DR EMBL; AK007707; BAB25202.1; -; mRNA.
DR EMBL; AK050027; BAC34036.1; -; mRNA.
DR EMBL; AK077277; BAC36725.1; -; mRNA.
DR EMBL; AK150936; BAE29971.1; -; mRNA.
DR EMBL; AL645847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115504; AAI15505.1; -; mRNA.
DR EMBL; BC115505; AAI15506.1; -; mRNA.
DR CCDS; CCDS24834.1; -.
DR RefSeq; NP_080486.1; NM_026210.4.
DR AlphaFoldDB; Q9D8T4; -.
DR BioGRID; 212238; 1.
DR STRING; 10090.ENSMUSP00000014321; -.
DR iPTMnet; Q9D8T4; -.
DR PhosphoSitePlus; Q9D8T4; -.
DR EPD; Q9D8T4; -.
DR jPOST; Q9D8T4; -.
DR MaxQB; Q9D8T4; -.
DR PaxDb; Q9D8T4; -.
DR PeptideAtlas; Q9D8T4; -.
DR PRIDE; Q9D8T4; -.
DR ProteomicsDB; 300065; -.
DR DNASU; 67510; -.
DR Ensembl; ENSMUST00000014321; ENSMUSP00000014321; ENSMUSG00000014177.
DR GeneID; 67510; -.
DR KEGG; mmu:67510; -.
DR UCSC; uc007jkh.1; mouse.
DR CTD; 51030; -.
DR MGI; MGI:1914760; Tvp23b.
DR VEuPathDB; HostDB:ENSMUSG00000014177; -.
DR eggNOG; KOG3195; Eukaryota.
DR GeneTree; ENSGT00390000004428; -.
DR HOGENOM; CLU_074845_3_0_1; -.
DR InParanoid; Q9D8T4; -.
DR OMA; DGNNHWK; -.
DR OrthoDB; 1356321at2759; -.
DR PhylomeDB; Q9D8T4; -.
DR TreeFam; TF312906; -.
DR BioGRID-ORCS; 67510; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Tvp23b; mouse.
DR PRO; PR:Q9D8T4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D8T4; protein.
DR Bgee; ENSMUSG00000014177; Expressed in otolith organ and 219 other tissues.
DR Genevisible; Q9D8T4; MM.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR008564; TVP23-like.
DR PANTHER; PTHR13019; PTHR13019; 1.
DR Pfam; PF05832; DUF846; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..205
FT /note="Golgi apparatus membrane protein TVP23 homolog B"
FT /id="PRO_0000212829"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:17242355"
SQ SEQUENCE 205 AA; 23305 MW; 4E55E71E681A85CD CRC64;
MLSQDSNDDT EDVSLFDAEE ETTNRPRKSK IRHPVASFFH LFFRVSAVVV YLLCELLSSS
FIACMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG KSHWVFESRK STPQDNKTIS
EAESRIFWLG LIACPVLWVI FAFSALFSFR VKWLAVVIMG VVLQGANLYG YIRCKVGSKK
NLTSMATSYL GKQFLRQNTG DGQTS
