TVA29_HUMAN
ID TVA29_HUMAN Reviewed; 119 AA.
AC P04437; A0JD25;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=T cell receptor alpha variable 29/delta variable 5 {ECO:0000303|Ref.4};
DE Flags: Precursor;
GN Name=TRAV29DV5 {ECO:0000303|Ref.4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2426193; DOI=10.1007/bf00372293;
RA Leiden J.M., Fraser J.D., Strominger J.L.;
RT "The complete primary structure of the T-cell receptor genes from an
RT alloreactive cytotoxic human T-lymphocyte clone.";
RL Immunogenetics 24:17-23(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (IMGT ALLELE TRAV29/DV5*01).
RX PubMed=9110172; DOI=10.1101/gr.7.4.330;
RA Boysen C., Simon M.I., Hood L.;
RT "Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with
RT bacterial artificial chromosome clones.";
RL Genome Res. 7:330-338(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE TRAV29/DV5*01).
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NOMENCLATURE.
RA Lefranc M.P., Lefranc G.;
RT "The T Cell Receptor FactsBook.";
RL (In) Lefranc M.P., Lefranc G. (eds.);
RL The T Cell Receptor FactsBook., pp.1-397, Academic Press, London. (2001).
RN [5]
RP REVIEW ON T CELL REPERTOIRE DIVERSITY.
RX PubMed=15040585; DOI=10.1038/nri1292;
RA Nikolich-Zugich J., Slifka M.K., Messaoudi I.;
RT "The many important facets of T-cell repertoire diversity.";
RL Nat. Rev. Immunol. 4:123-132(2004).
RN [6]
RP REVIEW ON T CELL RECEPTOR-CD3 COMPLEX ASSEMBLY, AND SUBCELLULAR LOCATION.
RX PubMed=20452950; DOI=10.1101/cshperspect.a005140;
RA Wucherpfennig K.W., Gagnon E., Call M.J., Huseby E.S., Call M.E.;
RT "Structural biology of the T-cell receptor: insights into receptor
RT assembly, ligand recognition, and initiation of signaling.";
RL Cold Spring Harb. Perspect. Biol. 2:A005140-A005140(2010).
RN [7]
RP REVIEW ON T CELL RECEPTOR SIGNALING.
RX PubMed=23524462; DOI=10.1038/nri3403;
RA Brownlie R.J., Zamoyska R.;
RT "T cell receptor signalling networks: branched, diversified and bounded.";
RL Nat. Rev. Immunol. 13:257-269(2013).
RN [8]
RP NOMENCLATURE.
RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA Lefranc M.P.;
RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT of Immunoinformatics.";
RL Front. Immunol. 5:22-22(2014).
RN [9]
RP REVIEW ON FUNCTION.
RX PubMed=25493333; DOI=10.1146/annurev-immunol-032414-112334;
RA Rossjohn J., Gras S., Miles J.J., Turner S.J., Godfrey D.I., McCluskey J.;
RT "T cell antigen receptor recognition of antigen-presenting molecules.";
RL Annu. Rev. Immunol. 33:169-200(2015).
RN [10] {ECO:0007744|PDB:1BD2}
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 28-118, AND DISULFIDE BONDS.
RX PubMed=9586631; DOI=10.1016/s1074-7613(00)80546-4;
RA Ding Y.H., Smith K.J., Garboczi D.N., Utz U., Biddison W.E., Wiley D.C.;
RT "Two human T cell receptors bind in a similar diagonal mode to the HLA-
RT A2/Tax peptide complex using different TCR amino acids.";
RL Immunity 8:403-411(1998).
CC -!- FUNCTION: V region of the variable domain of T cell receptor (TR) alpha
CC chain that participates in the antigen recognition (PubMed:24600447).
CC Alpha-beta T cell receptors are antigen specific receptors which are
CC essential to the immune response and are present on the cell surface of
CC T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH)
CC complexes that are displayed by antigen presenting cells (APC), a
CC prerequisite for efficient T cell adaptive immunity against pathogens
CC (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates
CC TR-CD3 clustering on the cell surface and intracellular activation of
CC LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247
CC enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT,
CC which recruits numerous signaling molecules to form the LAT
CC signalosome. The LAT signalosome propagates signal branching to three
CC major signaling pathways, the calcium, the mitogen-activated protein
CC kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB)
CC pathways, leading to the mobilization of transcription factors that are
CC critical for gene expression and essential for T cell growth and
CC differentiation (PubMed:23524462). The T cell repertoire is generated
CC in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped
CC by intrathymic selection events to generate a peripheral T cell pool of
CC self-MH restricted, non-autoaggressive T cells. Post-thymic interaction
CC of alpha-beta TR with the pMH complexes shapes TR structural and
CC functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585,
CC ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447,
CC ECO:0000303|PubMed:25493333}.
CC -!- SUBUNIT: Alpha-beta TR is a heterodimer composed of an alpha and beta
CC chain; disulfide-linked. The alpha-beta TR is associated with the
CC transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR
CC or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in
CC the endoplasmic reticulum where a single alpha-beta TR heterodimer
CC associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer
CC and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E
CC and CD3G-CD3E heterodimers preferentially associate with TR alpha and
CC TR beta chains, respectively. The association of the CD247 homodimer is
CC the last step of TcR assembly in the endoplasmic reticulum and is
CC required for transport to the cell surface.
CC {ECO:0000303|PubMed:20452950}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
CC -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC IMGT allele TRAV29/DV5*01. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA60627.1; Type=Miscellaneous discrepancy; Note=Chimeric mRNA corresponding to regions V and J of T cell receptor (TR) alpha chain.; Evidence={ECO:0000305};
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DR EMBL; M15565; AAA60627.1; ALT_SEQ; mRNA.
DR EMBL; AE000521; AAB69028.1; -; Genomic_DNA.
DR EMBL; AC245470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A02016; RWHU7A.
DR PDB; 1BD2; X-ray; 2.50 A; D=28-118.
DR PDBsum; 1BD2; -.
DR AlphaFoldDB; P04437; -.
DR SMR; P04437; -.
DR ChEMBL; CHEMBL3580506; -.
DR IMGT_GENE-DB; TRAV29DV5; -.
DR GlyGen; P04437; 1 site.
DR BioMuta; TCRA; -.
DR BioMuta; TRAV29DV5; -.
DR DMDM; 136488; -.
DR MassIVE; P04437; -.
DR PeptideAtlas; P04437; -.
DR PRIDE; P04437; -.
DR ProteomicsDB; 51712; -.
DR Ensembl; ENST00000390458.3; ENSP00000452209.1; ENSG00000211810.3.
DR UCSC; uc058zek.1; human.
DR GeneCards; TRAV29DV5; -.
DR HGNC; HGNC:12127; TRAV29DV5.
DR HPA; ENSG00000211810; Tissue enriched (lymphoid).
DR neXtProt; NX_P04437; -.
DR OpenTargets; ENSG00000211810; -.
DR VEuPathDB; HostDB:ENSG00000211810; -.
DR GeneTree; ENSGT00940000153130; -.
DR InParanoid; P04437; -.
DR OMA; LFDYFLW; -.
DR PhylomeDB; P04437; -.
DR PathwayCommons; P04437; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-HSA-202424; Downstream TCR signaling.
DR Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-HSA-202433; Generation of second messenger molecules.
DR Reactome; R-HSA-389948; PD-1 signaling.
DR ChiTaRS; TRAV29DV5; human.
DR Pharos; P04437; Tdark.
DR PRO; PR:P04437; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P04437; protein.
DR Bgee; ENSG00000211810; Expressed in lymph node and 69 other tissues.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR GO; GO:0042287; F:MHC protein binding; NAS:UniProtKB.
DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Cell membrane; Disulfide bond;
KW Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Signal; T cell receptor.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..119
FT /note="T cell receptor alpha variable 29/delta variable 5"
FT /evidence="ECO:0000255"
FT /id="PRO_0000033593"
FT DOMAIN 22..>119
FT /note="Ig-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:9586631, ECO:0007744|PDB:1BD2"
FT CONFLICT 119
FT /note="S -> K (in Ref. 1; AAA60627)"
FT /evidence="ECO:0000305"
FT NON_TER 119
FT STRAND 35..40
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 58..64
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 70..77
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 88..93
FT /evidence="ECO:0007829|PDB:1BD2"
FT TURN 94..97
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 98..105
FT /evidence="ECO:0007829|PDB:1BD2"
FT HELIX 108..110
FT /evidence="ECO:0007829|PDB:1BD2"
FT STRAND 112..118
FT /evidence="ECO:0007829|PDB:1BD2"
SQ SEQUENCE 119 AA; 13438 MW; 371B58FAB264B82B CRC64;
MAMLLGASVL ILWLQPDWVN SQQKNDDQQV KQNSPSLSVQ EGRISILNCD YTNSMFDYFL
WYKKYPAEGP TFLISISSIK DKNEDGRFTV FLNKSAKHLS LHIVPSQPGD SAVYFCAAS
