ID   TVB1_MOUSE              Reviewed;         135 AA.
AC   P01734;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=T-cell receptor beta chain V region 3H.25;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2580639; DOI=10.1016/0092-8674(85)90345-9;
RA   Goverman J., Minard K., Shastri N., Hunkapiller T., Hansburg D.,
RA   Sercarz E., Hood L.;
RT   "Rearranged beta T cell receptor genes in a helper T cell clone specific
RT   for lysozyme: no correlation between V beta and MHC restriction.";
RL   Cell 40:859-867(1985).
CC   -!- MISCELLANEOUS: This T-cell clone expresses only a single V-beta chain
CC       segment although it has three rearrangements in the beta chain family.
CC   -!- MISCELLANEOUS: This rearranged V-beta chain segment, specific for
CC       chicken egg-white lysozyme and I-A(b), is the same as that expressed in
CC       a T-helper cell specific for cytochrome C and an I-E(k) MHC molecule.
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DR   EMBL; M12415; AAA40249.1; -; Genomic_DNA.
DR   PIR; A02003; RWMSBV.
DR   AlphaFoldDB; P01734; -.
DR   SMR; P01734; -.
DR   IntAct; P01734; 1.
DR   PRIDE; P01734; -.
DR   UCSC; uc009boo.1; mouse.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01734; protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin domain;
KW   Receptor; Reference proteome; Signal; T cell receptor.
FT   SIGNAL          1..20
FT   CHAIN           21..135
FT                   /note="T-cell receptor beta chain V region 3H.25"
FT                   /id="PRO_0000033598"
FT   REGION          21..115
FT                   /note="V segment"
FT   REGION          116..118
FT                   /note="D segment"
FT   REGION          119..135
FT                   /note="J segment"
FT   DISULFID        42..111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         135
SQ   SEQUENCE   135 AA;  15123 MW;  C0FF1DDACF37E76D CRC64;
     MATRLLCYTV LCLLGARILN SKVIQTPRYL VKGQGQKAKM RCIPEKGHPV VFWYQQNKNN
     EFKFLINFQN QEVLQQIDMT EKRFSAECPS NSPCSLEIQS SEAGDSALYL CASSLFGTSD
     YTFGSGTRLL VIGKA