ID   TVG11_HUMAN             Reviewed;         119 AA.
AC   A0A075B6L2;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 2.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Probable non-functional T cell receptor gamma variable 11;
DE   Flags: Precursor;
GN   Name=TRGV11 {ECO:0000303|Ref.3, ECO:0000312|HGNC:HGNC:12286};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE TRGV11*01).
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=9619395; DOI=10.1159/000019049;
RA   Lefranc M.P.;
RT   "IMGT (ImMunoGeneTics) locus on focus. A new section of Experimental and
RT   Clinical Immunogenetics.";
RL   Exp. Clin. Immunogenet. 15:1-7(1998).
RN   [3]
RP   NOMENCLATURE.
RA   Lefranc M.P., Lefranc G.;
RT   "The T Cell Receptor FactsBook.";
RL   (In) Lefranc M.P., Lefranc G. (eds.);
RL   The T Cell Receptor FactsBook., pp.1-397, Academic Press, London. (2001).
RN   [4]
RP   REVIEW ON FUNCTION AND ANTIGEN RECOGNITION.
RX   PubMed=23348415; DOI=10.1038/nri3384;
RA   Vantourout P., Hayday A.;
RT   "Six-of-the-best: unique contributions of gammadelta T cells to
RT   immunology.";
RL   Nat. Rev. Immunol. 13:88-100(2013).
RN   [5]
RP   REVIEW ONGAMMA DELTA T CELL RECEPTOR DIVERSITY.
RX   PubMed=24387714; DOI=10.1146/annurev-immunol-032713-120216;
RA   Chien Y.H., Meyer C., Bonneville M.;
RT   "gammadelta T cells: first line of defense and beyond.";
RL   Annu. Rev. Immunol. 32:121-155(2014).
RN   [6]
RP   NOMENCLATURE.
RX   PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA   Lefranc M.P.;
RT   "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT   of Immunoinformatics.";
RL   Front. Immunol. 5:22-22(2014).
RN   [7]
RP   REVIEW ON T CELL RECEPTOR SIGNALING, AND SUBUNIT.
RX   PubMed=25674089; DOI=10.3389/fimmu.2015.00015;
RA   Ribeiro S.T., Ribot J.C., Silva-Santos B.;
RT   "Five Layers of Receptor Signaling in gammadelta T-Cell Differentiation and
RT   Activation.";
RL   Front. Immunol. 6:15-15(2015).
RN   [8]
RP   REVIEW ON FUNCTION.
RX   PubMed=28920588; DOI=10.1038/nri.2017.101;
RA   Nielsen M.M., Witherden D.A., Havran W.L.;
RT   "gammadelta T cells in homeostasis and host defence of epithelial barrier
RT   tissues.";
RL   Nat. Rev. Immunol. 17:733-745(2017).
CC   -!- FUNCTION: Probable non-functional open reading frame (ORF) of V region
CC       of the variable domain of T cell receptor (TR) gamma chain
CC       (PubMed:24600447). Non-functional ORF generally cannot participate in
CC       the synthesis of a productive T cell receptor (TR) chain due to altered
CC       V-(D)-J or switch recombination and/or splicing site (at mRNA level)
CC       and/or conserved amino acid change (protein level) (PubMed:9619395).
CC       Gamma-delta TRs recognize a variety of self and foreign non-peptide
CC       antigens frequently expressed at the epithelial boundaries between the
CC       host and external environment, including endogenous lipids presented by
CC       MH-like protein CD1D and phosphoantigens presented by butyrophilin-like
CC       molecule BTN3A1. Upon antigen recognition induces rapid, innate-like
CC       immune responses involved in pathogen clearance and tissue repair
CC       (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex
CC       to antigen triggers phosphorylation of immunoreceptor tyrosine-based
CC       activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases,
CC       allowing the recruitment, phosphorylation, and activation of ZAP70 that
CC       facilitates phosphorylation of the scaffolding proteins LCP2 and LAT.
CC       This lead to the formation of a supramolecular signalosome that
CC       recruits the phospholipase PLCG1, resulting in calcium mobilization and
CC       ERK activation, ultimately leading to T cell expansion and
CC       differentiation into effector cells (PubMed:25674089). Gamma-delta TRs
CC       are produced through somatic rearrangement of a limited repertoire of
CC       variable (V), diversity (D), and joining (J) genes. The potential
CC       diversity of gamma-delta TRs is conferred by the unique ability to
CC       rearrange (D) genes in tandem and to utilize all three reading frames.
CC       The combinatorial diversity is considerably increased by the sequence
CC       exonuclease trimming and random nucleotide (N) region additions which
CC       occur during the V-(D)-J rearrangements (PubMed:24387714).
CC       {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714,
CC       ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089,
CC       ECO:0000303|PubMed:28920588}.
CC   -!- SUBUNIT: Most probably, the gamma-delta TR is not assembled due to
CC       incorrect folding of the gamma chain (Probable). Gamma-delta TR is a
CC       heterodimer composed of a gamma and delta chain; disulfide-linked. The
CC       gamma-delta TR is associated with the transmembrane signaling CD3
CC       coreceptor proteins following the stoichiometry: a single gamma-delta
CC       TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E
CC       heterodimer and one CD247 homodimer forming a stable octomeric
CC       structure. Upon activation, gamma-delta TR complex associates with
CC       FCER1G to initiate intracellular signaling.
CC       {ECO:0000303|PubMed:25674089, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
CC   -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC       IMGT allele TRGV11*01. {ECO:0000305}.
CC   -!- CAUTION: Most probably a non-functional protein that cannot participate
CC       to the synthesis of a productive T cell receptor (TR) chain due to both
CC       an altered splicing site and a mutation at position 39, corresponding
CC       to the first cysteine from the disulfide bridge, potentially leading to
CC       uncorrect folding (PubMed:9619395). {ECO:0000303|PubMed:9619395,
CC       ECO:0000305}.
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DR   EMBL; AC006033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A075B6L2; -.
DR   SMR; A0A075B6L2; -.
DR   GlyGen; A0A075B6L2; 1 site.
DR   BioMuta; TRGV11; -.
DR   Ensembl; ENST00000390340.2; ENSP00000374863.2; ENSG00000211693.2.
DR   UCSC; uc064cxu.1; human.
DR   GeneCards; TRGV11; -.
DR   HGNC; HGNC:12286; TRGV11.
DR   neXtProt; NX_A0A075B6L2; -.
DR   VEuPathDB; HostDB:ENSG00000211693; -.
DR   HOGENOM; CLU_077975_7_0_1; -.
DR   PhylomeDB; A0A075B6L2; -.
DR   SignaLink; A0A075B6L2; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A0A075B6L2; protein.
DR   Bgee; ENSG00000211693; Expressed in blood and 15 other tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Cell membrane; Glycoprotein; Immunity;
KW   Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW   T cell receptor.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..119
FT                   /note="Probable non-functional T cell receptor gamma
FT                   variable 11"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000450774"
FT   DOMAIN          23..>119
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         119
SQ   SEQUENCE   119 AA;  13602 MW;  0FE3E683D064833C CRC64;
     MPLVVAVIFF SLWVFALGQL EQPEISISRP ANKSAHISWK ASIQGFSSKI IHWYWQKPNK
     GLEYLLHVFL TISAQDCSGG KTKKLEVSKN AHTSTSTLKI KFLEKEDEVV YHCACWIRH