TVP23_YEAST
ID TVP23_YEAST Reviewed; 199 AA.
AC P38962; D6VS71;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Golgi apparatus membrane protein TVP23;
DE AltName: Full=TLG2 compartment vesicle protein of 23 kDa;
GN Name=TVP23; OrderedLocusNames=YDR084C; ORFNames=D4466;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=16107716; DOI=10.1128/mcb.25.17.7696-7710.2005;
RA Inadome H., Noda Y., Adachi H., Yoda K.;
RT "Immunoisolation of the yeast Golgi subcompartments and characterization of
RT a novel membrane protein, Svp26, discovered in the Sed5-containing
RT compartments.";
RL Mol. Cell. Biol. 25:7696-7710(2005).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH YIP4 AND YIP5.
RX PubMed=17178117; DOI=10.1016/j.yexcr.2006.11.008;
RA Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.;
RT "Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-
RT containing Golgi/endosome compartments of Saccharomyces cerevisiae.";
RL Exp. Cell Res. 313:688-697(2007).
CC -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking.
CC {ECO:0000269|PubMed:17178117}.
CC -!- SUBUNIT: Interacts with YIP4 and YIP5. {ECO:0000269|PubMed:17178117}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:16107716, ECO:0000269|PubMed:17178117}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:16107716,
CC ECO:0000269|PubMed:17178117}.
CC -!- MISCELLANEOUS: Present with 1040 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the TVP23 family. {ECO:0000305}.
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DR EMBL; Z46796; CAA86806.1; -; Genomic_DNA.
DR EMBL; X82086; CAA57611.1; -; Genomic_DNA.
DR EMBL; Z74380; CAA98904.1; -; Genomic_DNA.
DR EMBL; AY557674; AAS56000.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11931.1; -; Genomic_DNA.
DR PIR; S48771; S48771.
DR RefSeq; NP_010369.3; NM_001180392.3.
DR AlphaFoldDB; P38962; -.
DR BioGRID; 32140; 58.
DR DIP; DIP-1822N; -.
DR IntAct; P38962; 16.
DR MINT; P38962; -.
DR STRING; 4932.YDR084C; -.
DR MaxQB; P38962; -.
DR PaxDb; P38962; -.
DR PRIDE; P38962; -.
DR EnsemblFungi; YDR084C_mRNA; YDR084C; YDR084C.
DR GeneID; 851657; -.
DR KEGG; sce:YDR084C; -.
DR SGD; S000002491; TVP23.
DR VEuPathDB; FungiDB:YDR084C; -.
DR eggNOG; KOG3195; Eukaryota.
DR GeneTree; ENSGT00390000004428; -.
DR HOGENOM; CLU_1190470_0_0_1; -.
DR InParanoid; P38962; -.
DR OMA; DGNNHWK; -.
DR BioCyc; YEAST:G3O-29689-MON; -.
DR PRO; PR:P38962; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P38962; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:SGD.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IGI:SGD.
DR InterPro; IPR008564; TVP23-like.
DR PANTHER; PTHR13019; PTHR13019; 1.
DR Pfam; PF05832; DUF846; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..199
FT /note="Golgi apparatus membrane protein TVP23"
FT /id="PRO_0000212837"
FT TRANSMEM 18..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 199 AA; 23148 MW; 516BBCBB80F88BCF CRC64;
MDQARNFYNT ILKSSHPLLL SFHLAGKAVP IVFYIIGSMF LNFTPQFITV VLLLSFDFYL
TKNITGRKLV QLRWWYDSTD VNKDSNFTFE SYKQYAPGPP INAIDSKLFW WSMYVTPVIW
GVFAVLCLLR LKIFYLILVI VAMCLTAWNT YGFRCCDRWE PNSGQSDGQD TNNWFALPSV
PGFENLSRLA NIQSFFQRQ
