ID   TVP38_ASHGO             Reviewed;         307 AA.
AC   Q759P7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Golgi apparatus membrane protein TVP38;
GN   Name=TVP38; OrderedLocusNames=ADR226C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC       spindle migration.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:P36164}.
CC   -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016817; AAS52146.1; -; Genomic_DNA.
DR   RefSeq; NP_984322.1; NM_209675.1.
DR   AlphaFoldDB; Q759P7; -.
DR   STRING; 33169.AAS52146; -.
DR   EnsemblFungi; AAS52146; AAS52146; AGOS_ADR226C.
DR   GeneID; 4620484; -.
DR   KEGG; ago:AGOS_ADR226C; -.
DR   eggNOG; KOG3140; Eukaryota.
DR   HOGENOM; CLU_041954_1_1_1; -.
DR   InParanoid; Q759P7; -.
DR   OMA; KWQALET; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0000022; P:mitotic spindle elongation; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR032816; SNARE_assoc.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Golgi apparatus membrane protein TVP38"
FT                   /id="PRO_0000343059"
FT   TOPO_DOM        1..71
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..143
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..262
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          139..250
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36164"
SQ   SEQUENCE   307 AA;  35133 MW;  0817057630482D2E CRC64;
     MADHYEARTS SQGALNVDRR TSISNENFFD IEEEDFLDMY PLSARQRLIY QCKRSSRKLL
     NTFMDLPLWK RAAVLLLCGG ATVSALVMMV FHKSILERMI KISNELRSWW YTPFIFFLLI
     FFVSFPPLIG FSMLCTSAGL VYGVSFKGWL IISLGTVLGS IAAFSVFKTV FRSYAERLIR
     LNDKFEALAS ILQDHNSYWI IALLRLCPFP YSLTNGAIAG VYGISIRNFS IAQVLTTPKL
     FMYLFIGSRL KNLGESSSTA TKLFDILSIL FAIIALTATA SILYYKTKER YLELQRRNQD
     RFDTLNF