TVP38_ASPFU
ID TVP38_ASPFU Reviewed; 418 AA.
AC Q4WQJ2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Golgi apparatus membrane protein tvp38;
GN Name=tvp38; ORFNames=AFUA_4G13010;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC spindle migration.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC there is no evidence that this domain associates with SNARE proteins,
CC it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC {ECO:0000250|UniProtKB:P36164}.
CC -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR EMBL; AAHF01000005; EAL89492.1; -; Genomic_DNA.
DR RefSeq; XP_751530.1; XM_746437.1.
DR AlphaFoldDB; Q4WQJ2; -.
DR STRING; 746128.CADAFUBP00006811; -.
DR EnsemblFungi; EAL89492; EAL89492; AFUA_4G13010.
DR GeneID; 3509185; -.
DR KEGG; afm:AFUA_4G13010; -.
DR VEuPathDB; FungiDB:Afu4g13010; -.
DR eggNOG; KOG3140; Eukaryota.
DR HOGENOM; CLU_041954_0_0_1; -.
DR InParanoid; Q4WQJ2; -.
DR OMA; YHDEFTD; -.
DR OrthoDB; 1327131at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0000022; P:mitotic spindle elongation; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR032816; SNARE_assoc.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..418
FT /note="Golgi apparatus membrane protein tvp38"
FT /id="PRO_0000343062"
FT TOPO_DOM 1..81
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..157
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..273
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..258
FT /note="VTT domain"
FT /evidence="ECO:0000250|UniProtKB:P36164"
FT REGION 367..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 46735 MW; 4A443718633C8D06 CRC64;
MPADYTSTAR ALSLPMSPAE SLSPAEEDTR PLWSHLASSR RNTASPSVRE STGLRDQVVN
QATKMLRRTK KTWRRLTFWQ RIGAIGAALL AILLGLSFMI FTGQVFFWLG PVAEKWEQSW
LAFFVLWLCV FFVSFPPLVG WSTFGTISGF IYGIWKGWIL YATATVLGST CSFIVSRTIL
SKFVNRMMER DKRFAALALT LKYDGLKLLC MIRLCPLPYS VCNGAVSTFP TVHPLMYGLA
TALITPKLLV PAFIGSRIRI LSEKNEEMSA ASKAVNICSI ILTIGIGVFT GWYIYRRTLA
RAKELEAKER ADIRRSLEAD HAAHRPHGSF SEDPDVNTAA TTLARDEEER IGFNDFDDDN
VDLVIDDDSG SEISPNLTKK QFPGPYRDEF TDNDSDVFGD GDGPDSQMFR LHTHVRSG
