TVP38_ASPOR
ID TVP38_ASPOR Reviewed; 414 AA.
AC Q2UUJ9;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Golgi apparatus membrane protein tvp38;
GN Name=tvp38; ORFNames=AO090009000287;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC spindle migration.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC there is no evidence that this domain associates with SNARE proteins,
CC it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC {ECO:0000250|UniProtKB:P36164}.
CC -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE54766.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP007150; BAE54766.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001816768.2; XM_001816716.2.
DR AlphaFoldDB; Q2UUJ9; -.
DR STRING; 510516.Q2UUJ9; -.
DR VEuPathDB; FungiDB:AO090009000287; -.
DR OMA; YHDEFTD; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032816; SNARE_assoc.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..414
FT /note="Golgi apparatus membrane protein tvp38"
FT /id="PRO_0000343063"
FT TOPO_DOM 1..90
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..155
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..271
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..256
FT /note="VTT domain"
FT /evidence="ECO:0000250|UniProtKB:P36164"
FT REGION 317..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 414 AA; 45893 MW; 0223D38189620F40 CRC64;
MPADYTSTAR ALSLPTSPSE SLSPADNDSY PPWSHLASGR SNPAHPSERP TLWKQVTHRL
NETSQRMMAI WRRLSFWQKV GAAAAALLAN LLGIGFLVFT GKVFIWLGPV AEQWEQSVVA
YTVLWLCVFF VSFPPLVGWS TFGTISGYIF GVWKGWFLYA SATVLGSTCS FVVSRTILSK
FVNRMMERDK RFAALALTLK YDGLKLLCMI RLCPLPYSVC NGAVSTFPTV QPLMYGLATA
IVTPKLLVPA FVGSRIRLLS EKGEEMSAGS KAVNIISIIV TVAIGIFTGW YIYKRTMARA
KELEAQERAD IRRSLQADHA DRRPHHSFSE DPDVNTAATT LARDEEERLG FHDFDDDNVD
LAIDDESGGE NSPRLQSGGP YRDEFTDNDS DDVFKNGDGG EGETYGLHTH VRKS
