ID   TVP38_KLULA             Reviewed;         305 AA.
AC   Q6CXJ8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Golgi apparatus membrane protein TVP38;
GN   Name=TVP38; OrderedLocusNames=KLLA0A07667g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC       spindle migration.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:P36164}.
CC   -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02929.1; -; Genomic_DNA.
DR   RefSeq; XP_451341.1; XM_451341.1.
DR   AlphaFoldDB; Q6CXJ8; -.
DR   STRING; 28985.XP_451341.1; -.
DR   EnsemblFungi; CAH02929; CAH02929; KLLA0_A07667g.
DR   GeneID; 2896436; -.
DR   KEGG; kla:KLLA0_A07667g; -.
DR   eggNOG; KOG3140; Eukaryota.
DR   HOGENOM; CLU_041954_1_1_1; -.
DR   InParanoid; Q6CXJ8; -.
DR   OMA; KWQALET; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IEA:EnsemblFungi.
DR   GO; GO:0000022; P:mitotic spindle elongation; IEA:EnsemblFungi.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:EnsemblFungi.
DR   InterPro; IPR032816; SNARE_assoc.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="Golgi apparatus membrane protein TVP38"
FT                   /id="PRO_0000343070"
FT   TOPO_DOM        1..69
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..147
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..262
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          139..250
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36164"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34771 MW;  8CC0349E7394FEAD CRC64;
     MADLYEARVS SGGLSRPSDT DFLDSNDNFD DLDDDFLDIY NLSWRQRIVQ HGKRHLRNGK
     DKFNALSRRK KALVVFLGVL EIILIFITVV KREAIMKGLV DASNDLRQKW YTPLVLMLLI
     LAVSFPPLIG YSFLSLSTGL IYGLSFKGWF ILAMSTVIGS VLSFTVFQRL LHSHAERLIR
     MNPKLEAVSS VLQGNDSYWM IALIRLCPFP YSFINGAIAG IYGISIKNFA IANIITTPKA
     VIYLFVGERL KNMGETDSGS TRLINFISIL LANGFLILTT WFLYYRFKKR YLELQSEQQN
     SFDIF