ID   TVP38_NEOFI             Reviewed;         418 AA.
AC   A1CW44;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Golgi apparatus membrane protein tvp38;
GN   Name=tvp38; ORFNames=NFIA_103340;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC       spindle migration.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:P36164}.
CC   -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR   EMBL; DS027685; EAW24846.1; -; Genomic_DNA.
DR   RefSeq; XP_001266743.1; XM_001266742.1.
DR   AlphaFoldDB; A1CW44; -.
DR   STRING; 36630.CADNFIAP00009570; -.
DR   EnsemblFungi; EAW24846; EAW24846; NFIA_103340.
DR   GeneID; 4593262; -.
DR   KEGG; nfi:NFIA_103340; -.
DR   VEuPathDB; FungiDB:NFIA_103340; -.
DR   eggNOG; KOG3140; Eukaryota.
DR   HOGENOM; CLU_041954_0_0_1; -.
DR   OMA; YHDEFTD; -.
DR   OrthoDB; 1327131at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032816; SNARE_assoc.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..418
FT                   /note="Golgi apparatus membrane protein tvp38"
FT                   /id="PRO_0000343071"
FT   TOPO_DOM        1..81
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..157
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..273
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..418
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..258
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36164"
FT   REGION          362..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46656 MW;  493F8FD6A2C26A65 CRC64;
     MPADYTSTAR ALSLPMSPAE SLSPAEEDTQ PLWSHLASSR RNTASPSARE STGLRDQVVN
     QATKMLRRTK KTWRRLTFWQ RIGAIGAALL AILLGLAFMI FTGQVFFWLG PVAEKWEQSW
     LAFFVLWLCV FFVSFPPLVG WSTFGTIAGF IFGIWKGWIL YATATVLGST CSFIVSRTIL
     SKFVNRMMER DKRFAALALT LKYDGLKLLC MIRLCPLPYS VCNGAVSTFP TVHPLMYGLA
     TALITPKLLV PAFIGSRIRI LSEKNEEMSA GSKAVNICSI ILTIGIGIFT GWYIYRRTLA
     RAKELEAKER ADIRRSLQAD HAAHHPHGSF SEDPDVNTAA TTLARDEEER IGFNDFDDDN
     VDLVIDDESG SENSPNLTKK QFQGPYRDEF TDNDSDVFGD GDGPDSQMFR LHTHVRSG