ID   TVP38_VANPO             Reviewed;         319 AA.
AC   A7TMU9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Golgi apparatus membrane protein TVP38;
GN   Name=TVP38; ORFNames=Kpol_1030p31;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC       spindle migration.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:P36164}.
CC   -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR   EMBL; DS480425; EDO16421.1; -; Genomic_DNA.
DR   RefSeq; XP_001644279.1; XM_001644229.1.
DR   AlphaFoldDB; A7TMU9; -.
DR   STRING; 436907.A7TMU9; -.
DR   EnsemblFungi; EDO16421; EDO16421; Kpol_1030p31.
DR   GeneID; 5544554; -.
DR   KEGG; vpo:Kpol_1030p31; -.
DR   eggNOG; KOG3140; Eukaryota.
DR   HOGENOM; CLU_041954_1_1_1; -.
DR   InParanoid; A7TMU9; -.
DR   OMA; KWQALET; -.
DR   OrthoDB; 1327131at2759; -.
DR   PhylomeDB; A7TMU9; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032816; SNARE_assoc.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Golgi apparatus membrane protein TVP38"
FT                   /id="PRO_0000343076"
FT   TOPO_DOM        1..76
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..118
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..143
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..232
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..267
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          144..255
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36164"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36058 MW;  CEE21814E7285CFF CRC64;
     MADNYEARTS SHYDNNATEF DDYFNEFDTG IGLGPDDEDD FLDIYNLSPR QRVVYQFRRT
     VNQFLSQYYA LEPWQRILLA IGGGLIGILA LLMLIFHNKI LHKLVEMSND LKEKWSTPIV
     LVTLIFFVAF PPMIGFSLLS TTTGLIYGIS FKGWVILAIG AVTGSICSFA LFKTILHSRA
     EKLIQMNRRF AAFASILQEN NSYWILALLR LCPFPYSLTN GAVGAVYGVS IKNFAIGNII
     TTPKLLIYLF IGSRIKNMGE TESSASKIFD LVSILLTVLA LGLTAWVLYF KTQKRYQQLQ
     DQSTINTSND LDIDQNFEI