ID   TVP38_YEAS7             Reviewed;         337 AA.
AC   A7A047;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Golgi apparatus membrane protein TVP38;
DE   AltName: Full=TLG2-vesicle protein of 38 kDa;
GN   Name=TVP38; ORFNames=SCY_3457;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Golgi membrane protein involved in vesicular trafficking and
CC       spindle migration.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The VTT domain was previously called the SNARE-assoc domain. As
CC       there is no evidence that this domain associates with SNARE proteins,
CC       it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.
CC       {ECO:0000250|UniProtKB:P36164}.
CC   -!- SIMILARITY: Belongs to the TVP38/TMEM64 family. {ECO:0000305}.
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DR   EMBL; AAFW02000152; EDN59990.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A047; -.
DR   SMR; A7A047; -.
DR   EnsemblFungi; EDN59990; EDN59990; SCY_3457.
DR   HOGENOM; CLU_041954_1_1_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032816; SNARE_assoc.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Golgi apparatus membrane protein TVP38"
FT                   /id="PRO_0000343077"
FT   TOPO_DOM        1..95
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..169
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..286
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        308..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          163..274
FT                   /note="VTT domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36164"
SQ   SEQUENCE   337 AA;  38311 MW;  7EA95DD4E5AF77FE CRC64;
     MSQSYEAGNA NMGQGEDDEF DGYFEDFDND IMPNSNNGQR VGTNAGLSFN DEVNVNDDDF
     LDIYNMSPRE RLMHNIRKNV QKLQFYFYSL RLWQQIIIVL LGIMLMIMGI LLLVFHNAIL
     HKVVVTSNDL REKMSTHFIL MVLIFFVAFP PMIGYSLLST TTGLIYGVSF EGWVTLALGS
     VTGSIASFVV FKTILHSRAE KLVHLNRRFE ALASILQENN SYWILALLRL CPFPYSLTNG
     AIAGVYGISV RNFSIANIIT TPKLFIYLFI GSRVKSLAES ESTGSRVFDL VSIIITLLIL
     SLTAWLLYFK TKKRYLELQN RDRQVSTDQL PELSFEV