位置:首页 > 蛋白库 > TWF1_XENLA
TWF1_XENLA
ID   TWF1_XENLA              Reviewed;         350 AA.
AC   Q68F50;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Twinfilin-1;
GN   Name=twf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actin-binding protein involved in motile and morphological
CC       processes. Inhibits actin polymerization, likely by sequestering G-
CC       actin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with G-actin; ADP-actin form. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. Twinfilin
CC       subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Molecular embrace - Issue 73
CC       of August 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/073";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079994; AAH79994.1; -; mRNA.
DR   RefSeq; NP_001087483.1; NM_001094014.1.
DR   AlphaFoldDB; Q68F50; -.
DR   SMR; Q68F50; -.
DR   DNASU; 447307; -.
DR   GeneID; 447307; -.
DR   KEGG; xla:447307; -.
DR   CTD; 447307; -.
DR   Xenbase; XB-GENE-865829; twf1.S.
DR   OrthoDB; 1578109at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 447307; Expressed in gastrula and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 3.40.20.10; -; 2.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR028458; Twinfilin.
DR   PANTHER; PTHR13759; PTHR13759; 1.
DR   Pfam; PF00241; Cofilin_ADF; 2.
DR   SMART; SM00102; ADF; 2.
DR   PROSITE; PS51263; ADF_H; 2.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..350
FT                   /note="Twinfilin-1"
FT                   /id="PRO_0000232407"
FT   DOMAIN          4..139
FT                   /note="ADF-H 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   DOMAIN          177..313
FT                   /note="ADF-H 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   REGION          316..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  40454 MW;  75654B74886ABA04 CRC64;
     MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE QEYDNFILPL
     LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML YAATRATVKK EFGGGHIKEE
     IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA EEELRQIKIK ETPTDIAVDT KHQTLQGIAF
     PIEKAAFQAL EQLREKRLNY VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL
     YKHSHEGDYL DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG
     DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024