ID   TWIST_DROER             Reviewed;         490 AA.
AC   Q8I1G0;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Protein twist;
GN   Name=twi {ECO:0000312|EMBL:AAO01011.1};
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:AAO01011.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12537575; DOI=10.1186/gb-2002-3-12-research0086;
RA   Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A., Gnirke A.,
RA   Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M., Park S., Stapleton M.,
RA   Wan K.H., George R.A., de Jong P.J., Botas J., Rubin G.M., Celniker S.E.;
RT   "Assessing the impact of comparative genomic sequence data on the
RT   functional annotation of the Drosophila genome.";
RL   Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
CC   -!- FUNCTION: Involved in the establishment and dorsoventral patterning of
CC       germ layers in the embryo. {ECO:0000250|UniProtKB:P10627}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Homodimer (By similarity). {ECO:0000250|UniProtKB:P10627}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AY190941; AAO01011.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8I1G0; -.
DR   SMR; Q8I1G0; -.
DR   STRING; 7220.FBpp0141366; -.
DR   eggNOG; KOG4447; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0031032; P:actomyosin structure organization; IEA:EnsemblMetazoa.
DR   GO; GO:0007369; P:gastrulation; ISS:UniProtKB.
DR   GO; GO:0007443; P:Malpighian tubule morphogenesis; ISS:UniProtKB.
DR   GO; GO:0001710; P:mesodermal cell fate commitment; ISS:UniProtKB.
DR   GO; GO:0055001; P:muscle cell development; IEA:EnsemblMetazoa.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; ISS:UniProtKB.
DR   GO; GO:0007435; P:salivary gland morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007370; P:ventral furrow formation; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR015789; Twist-related.
DR   PANTHER; PTHR23349:SF50; PTHR23349:SF50; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..490
FT                   /note="Protein twist"
FT                   /id="PRO_0000127477"
FT   DOMAIN          362..413
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          48..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  54495 MW;  A22FA05CE1A44BAB CRC64;
     MMSARSVSPK VLLDISYKPT LPNIMELQNN VIKLIQVEQQ AYMQSGYQLQ HQQQHLHSHQ
     HHQQHQQQQQ QHTQYAPLPS EYAAYGITEL EDTDYNIPSN EVLSTSSNQS AQSTSLEMNN
     NNTSSNNTSS GNNPSGFDGQ ASSGSSWNEH GKRARSSGDY DCQTGGSLVM QPEHKKLIHQ
     QQQQPQQQQQ HQQHIYVDYL PTTVDEVAAA QSCPGVQSTC TSPQSHFDFP DEELPEHKAQ
     VFLPLYNNQQ QSQQQPHQQN HAQMHFQNAY RQSFESYEPA NSLNGSAYSS SDRDDMEYAR
     HNALSSVSDL NGGVMSPACL ADDGSAGSLL DGSDAGGKAF RKPRRRLKRK PSKTEETDEF
     SNQRVMANVR ERQRTQSLND AFKSLQQIIP TLPSDKLSKI QTLKLATRYI DFLCRMLSSS
     DISLLKALEA QGSPSAYGSA SSLLSAAANG AEADLKCLRK ANGAPIIPPE KLSYLFGVWR
     MEGDAQHQKA