ID   TWIST_XENLA             Reviewed;         166 AA.
AC   P13903; Q0IHA6;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Twist-related protein;
DE   AltName: Full=T18;
DE   AltName: Full=X-twist;
GN   Name=twist1; Synonyms=xtwi;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2590945; DOI=10.1016/0092-8674(89)90612-0;
RA   Hopwood N.D., Pluck A., Gurdon J.B.;
RT   "A Xenopus mRNA related to Drosophila twist is expressed in response to
RT   induction in the mesoderm and the neural crest.";
RL   Cell 59:893-903(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor, which may be involved, with
CC       other proteins, in establishing the pattern of cell type-specific gene
CC       expression in mesodermal cell subgroups.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Homodimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Subset of mesodermal cells.
CC   -!- INDUCTION: Expressed in the mesoderm and the neural crest in response
CC       to two sequential early inductions (mesodermal and neural).
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DR   EMBL; M27730; AAA50008.1; -; mRNA.
DR   EMBL; BC123238; AAI23239.1; -; mRNA.
DR   PIR; A33637; A33637.
DR   RefSeq; NP_001079352.1; NM_001085883.1.
DR   AlphaFoldDB; P13903; -.
DR   SMR; P13903; -.
DR   BioGRID; 97279; 2.
DR   DNASU; 378698; -.
DR   GeneID; 378698; -.
DR   KEGG; xla:378698; -.
DR   CTD; 378698; -.
DR   Xenbase; XB-GENE-865309; twist1.S.
DR   OMA; MPEEDSC; -.
DR   OrthoDB; 1595261at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 378698; Expressed in neurula embryo and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0014029; P:neural crest formation; TAS:AgBase.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR015789; Twist-related.
DR   PANTHER; PTHR23349:SF64; PTHR23349:SF64; 2.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..166
FT                   /note="Twist-related protein"
FT                   /id="PRO_0000127493"
FT   DOMAIN          72..123
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   166 AA;  18796 MW;  BFA05DE6920EB606 CRC64;
     MMQEESSSPV SPVDSLSNSE EELDKQQSKR GCRKRRSARK SPEDPDSPIS VKRNKKASST
     GSSPQSFEEL QSQRVMANVR ERQRTQSLNE AFSSLRKIIP TLPSDKLSKI QTLKLASRYI
     DFLCQVLQSD ELDSKMASCS YVAHERLSYA FSVWRMEGAW SMSASH