ID   TWK12_CAEBR             Reviewed;         687 AA.
AC   A8X8I4;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=TWiK family of potassium channels protein 12;
GN   Name=twk-12 {ECO:0000312|EMBL:CAP28945.2}; ORFNames=CBG09670;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP28945.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000255}.
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DR   EMBL; HE600998; CAP28945.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8X8I4; -.
DR   EnsemblMetazoa; CBG09670.1; CBG09670.1; WBGene00031224.
DR   WormBase; CBG09670; CBP25527; WBGene00031224; Cbr-twk-12.
DR   eggNOG; KOG1418; Eukaryota.
DR   HOGENOM; CLU_476700_0_0_1; -.
DR   InParanoid; A8X8I4; -.
DR   OMA; RMAPNLM; -.
DR   OrthoDB; 1171809at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; PTHR11003; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW   Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..687
FT                   /note="TWiK family of potassium channels protein 12"
FT                   /id="PRO_0000397232"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        112..132
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        242..262
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..687
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          661..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   687 AA;  78854 MW;  B564419F96986274 CRC64;
     MTLFQKLQWF CQLIRLRAYY KFLLLIAYTL FGAWLFRFYE LQADIKRRAI YGNDTNLIRR
     QLAERWIEMH DDAVLRNNSV LRRRRAAEAV DWLLGELNLS DHMREFSEDT PWTWTGAMFY
     AGQLYTTIGY GYPTAKTDEG RICTVLYALF GIPCFLMYLK AIGKTLSKRL KKIYKRVRRS
     AFGKFLLPTR VTATKDGFED PDASAEERKR KPFPIPIAII LLIIWICFSA SMFCQWEKTW
     DFPSAVYFFI VSISTVGLGD MLFRTPDMMV FNFLLILFGL ALLSMCFELI TDRIAKWKQK
     RFDEHIKKVQ KMAFQVFEKD PFVEEAPPLG IRMAPNLMQI AATHVSEEKR GFFAELKDWF
     AGKVTDNVIQ SKLEDTDDES DEDEALEEFE SPQVATLTAN DLVVCTNGGA TRRVSKQSYA
     FSDVSNLSNS KIPPGNNYGQ LLDRIKAMEK FKPKKGDLDS RMFAKFLENK KLAKILEQTE
     LRELATVSCQ TDLSGLVVQR RNPKGRHARI GSCSSQSTMS TFLPRNNSHA PDEDSVMSIT
     FGDLKFDYIT EPLIDEYHLR ESNHSIFDFD DDEVVRIPQK MLVSRPGMPP PPPSRPSQLA
     SPLRALLEKE QKYDEDPEIQ LTPRRLASLT DVQARKVKLG YDENLQHARL VCGLLPQDFD
     SPSTSTSTSM IDSGYDLSKR DAPVNIV