TWK7_CAEEL
ID TWK7_CAEEL Reviewed; 557 AA.
AC P34410; P34411; Q629K0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=TWiK family of potassium channels protein 7;
GN Name=twk-7; Synonyms=twk-8; ORFNames=F22B7.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; FO080222; CCD62137.1; -; Genomic_DNA.
DR PIR; S44633; S44633.
DR PIR; S44635; S44635.
DR RefSeq; NP_498903.3; NM_066502.5.
DR AlphaFoldDB; P34410; -.
DR BioGRID; 56565; 1.
DR STRING; 6239.F22B7.7; -.
DR EPD; P34410; -.
DR PaxDb; P34410; -.
DR EnsemblMetazoa; F22B7.7.1; F22B7.7.1; WBGene00006662.
DR GeneID; 192073; -.
DR KEGG; cel:CELE_F22B7.7; -.
DR UCSC; F22B7.7; c. elegans.
DR CTD; 192073; -.
DR WormBase; F22B7.7; CE37508; WBGene00006662; twk-7.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_022504_0_0_1; -.
DR InParanoid; P34410; -.
DR OMA; PRRDGYM; -.
DR OrthoDB; 774951at2759; -.
DR PhylomeDB; P34410; -.
DR Reactome; R-CEL-1299344; TWIK-related spinal cord K+ channel (TRESK).
DR Reactome; R-CEL-1299361; TWIK-related alkaline pH activated K+ channel (TALK).
DR Reactome; R-CEL-1299503; TWIK related potassium channel (TREK).
DR Reactome; R-CEL-5576886; Phase 4 - resting membrane potential.
DR PRO; PR:P34410; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006662; Expressed in larva and 3 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01095; TASKCHANNEL.
PE 3: Inferred from homology;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..557
FT /note="TWiK family of potassium channels protein 7"
FT /id="PRO_0000101771"
FT TOPO_DOM 1..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 270..290
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 397..417
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 447..557
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 557 AA; 64212 MW; 4A7138B4BC8AB3A3 CRC64;
MTSSSRGYQR VDSSGDGGSL LMEEEGDNPH EALLHRNNDD YASTYHHVGV EYDSYEELER
HEMDDRVTEI PEGFHRRQRR NLIYGDDVAT DEELRVLRRE ALFGEEVTRA GLGRAEYYED
SHLIHSCDKS GHEDIDDESD DESKDEDEEE EETGIRKFAK LVLPHVALVL LTCTYTVIGA
LIFYSVEQPH EQMMKEQQLK LIYTRQNEFV DDLIRLAAGN ETKRYEWESL AERHMHNMSD
QLFVAFEKYF LTSNEVKKNA ATETWTFSSS IFFAVTVVTT IGYGNPVPVT NIGRIWCILF
SLLGIPLTLV TIADLGKFLS EHLVWLYGNY LKLKYLILSR HRKERREHVC EHCHSHGMGH
DMNIEEKRIP AFLVLAILIV YTAFGGVLMS KLEPWSFFTS FYWSFITMTT VGFGDLMPRR
DGYMYIILLY IILGLAITTM CIDLVGVQYI RKIHYFGRKI QDARSALAVV GGKVVLVSEL
YANLMQKRAR NMSREAFIVE NLYVSKHIIP FIPTDIRCIR YIDQTADAAT ISTSSSAIDM
QSCRFCHSRY SLNRAFK
