TWK9_CAEEL
ID TWK9_CAEEL Reviewed; 568 AA.
AC Q23435;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=TWiK family of potassium channels protein 9;
GN Name=twk-9; ORFNames=ZK1251.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15183729; DOI=10.1016/j.ydbio.2004.02.020;
RA Portman D.S., Emmons S.W.;
RT "Identification of C. elegans sensory ray genes using whole-genome
RT expression profiling.";
RL Dev. Biol. 270:499-512(2004).
CC -!- FUNCTION: Potassium channel protein that may be component of regulatory
CC network that controls ray development and function.
CC {ECO:0000303|PubMed:15183729}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in ray A-type neurons and cell bodies.
CC Also seen in head, pharyngeal and phasmid neurons, and in coelomocytes.
CC {ECO:0000269|PubMed:15183729}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000255}.
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DR EMBL; Z68222; CAA92504.2; -; Genomic_DNA.
DR PIR; T27725; T27725.
DR RefSeq; NP_501724.2; NM_069323.2.
DR AlphaFoldDB; Q23435; -.
DR STRING; 6239.ZK1251.8; -.
DR TCDB; 1.A.1.9.8; the voltage-gated ion channel (vic) superfamily.
DR PaxDb; Q23435; -.
DR EnsemblMetazoa; ZK1251.8a.1; ZK1251.8a.1; WBGene00006664.
DR GeneID; 177803; -.
DR KEGG; cel:CELE_ZK1251.8; -.
DR UCSC; ZK1251.8; c. elegans.
DR CTD; 177803; -.
DR WormBase; ZK1251.8a; CE40540; WBGene00006664; twk-9.
DR eggNOG; KOG1418; Eukaryota.
DR InParanoid; Q23435; -.
DR OMA; LSMQWLE; -.
DR OrthoDB; 1171809at2759; -.
DR PhylomeDB; Q23435; -.
DR Reactome; R-CEL-1299344; TWIK-related spinal cord K+ channel (TRESK).
DR Reactome; R-CEL-1299361; TWIK-related alkaline pH activated K+ channel (TALK).
DR Reactome; R-CEL-1299503; TWIK related potassium channel (TREK).
DR Reactome; R-CEL-5576886; Phase 4 - resting membrane potential.
DR PRO; PR:Q23435; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006664; Expressed in larva and 2 other tissues.
DR ExpressionAtlas; Q23435; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Potassium; Potassium channel;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..568
FT /note="TWiK family of potassium channels protein 9"
FT /id="PRO_0000101772"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 163..183
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 343..363
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..568
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..308
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 64533 MW; 6C47ED7AC4EEADA3 CRC64;
MKCSFHIPEK YQWASTLFVH VALIAGVAVY TVFGALSMQW LESPDRVRAL LKRELKPVES
LPPPPSISGL PDRITRVYLG EELAILDPGV HECLERTILT LFHDTKCDPY SFEHLNIELI
DRCYAEANVP IPEGYGGQPR KKIKNKEEEK DVIDETPAEK WSIGNSVIFA FTVITTIGYG
HVAPETFEGR LFLIFYGVIG VPFTLLTIAD LGMFLTRFLK NLLTMARRFA HYLVKLYQKA
KKQRNKSQKT SPVMPDSERS EVWNTGKEMK EMSMRTAREP GEGDEIEVIE NGNDENGKEE
DEEEPENNEP RKTEESIALG ITFTCYLVAG AKILSVYEPE MDFFKALYFN FVTLTTIGLG
DFVPKSFDYL LITLIYIGIG LALTTMAIEI AADLLKKLHY IGRKMENVGQ AVVWFGGKKM
TMKSLVKHLG DQFNIPEEEL ANFDMSAFVD NAIKVEKGEI ATLRKPPTPP VVFRERAFSF
SNVRNSSESA LKYVDDNRFS KTTQPTIYTV IIHETTRTID TLHNLADAIR RDPSIPRLDL
DVHYLTDMSA PTSFDENYLR TYTNARRK