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TWK9_CAEEL
ID   TWK9_CAEEL              Reviewed;         568 AA.
AC   Q23435;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=TWiK family of potassium channels protein 9;
GN   Name=twk-9; ORFNames=ZK1251.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=15183729; DOI=10.1016/j.ydbio.2004.02.020;
RA   Portman D.S., Emmons S.W.;
RT   "Identification of C. elegans sensory ray genes using whole-genome
RT   expression profiling.";
RL   Dev. Biol. 270:499-512(2004).
CC   -!- FUNCTION: Potassium channel protein that may be component of regulatory
CC       network that controls ray development and function.
CC       {ECO:0000303|PubMed:15183729}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in ray A-type neurons and cell bodies.
CC       Also seen in head, pharyngeal and phasmid neurons, and in coelomocytes.
CC       {ECO:0000269|PubMed:15183729}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000255}.
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DR   EMBL; Z68222; CAA92504.2; -; Genomic_DNA.
DR   PIR; T27725; T27725.
DR   RefSeq; NP_501724.2; NM_069323.2.
DR   AlphaFoldDB; Q23435; -.
DR   STRING; 6239.ZK1251.8; -.
DR   TCDB; 1.A.1.9.8; the voltage-gated ion channel (vic) superfamily.
DR   PaxDb; Q23435; -.
DR   EnsemblMetazoa; ZK1251.8a.1; ZK1251.8a.1; WBGene00006664.
DR   GeneID; 177803; -.
DR   KEGG; cel:CELE_ZK1251.8; -.
DR   UCSC; ZK1251.8; c. elegans.
DR   CTD; 177803; -.
DR   WormBase; ZK1251.8a; CE40540; WBGene00006664; twk-9.
DR   eggNOG; KOG1418; Eukaryota.
DR   InParanoid; Q23435; -.
DR   OMA; LSMQWLE; -.
DR   OrthoDB; 1171809at2759; -.
DR   PhylomeDB; Q23435; -.
DR   Reactome; R-CEL-1299344; TWIK-related spinal cord K+ channel (TRESK).
DR   Reactome; R-CEL-1299361; TWIK-related alkaline pH activated K+ channel (TALK).
DR   Reactome; R-CEL-1299503; TWIK related potassium channel (TREK).
DR   Reactome; R-CEL-5576886; Phase 4 - resting membrane potential.
DR   PRO; PR:Q23435; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006664; Expressed in larva and 2 other tissues.
DR   ExpressionAtlas; Q23435; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; PTHR11003; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Potassium; Potassium channel;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..568
FT                   /note="TWiK family of potassium channels protein 9"
FT                   /id="PRO_0000101772"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        163..183
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        343..363
FT                   /note="Pore-forming; Name=Pore-forming 2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        391..568
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          243..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..308
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  64533 MW;  6C47ED7AC4EEADA3 CRC64;
     MKCSFHIPEK YQWASTLFVH VALIAGVAVY TVFGALSMQW LESPDRVRAL LKRELKPVES
     LPPPPSISGL PDRITRVYLG EELAILDPGV HECLERTILT LFHDTKCDPY SFEHLNIELI
     DRCYAEANVP IPEGYGGQPR KKIKNKEEEK DVIDETPAEK WSIGNSVIFA FTVITTIGYG
     HVAPETFEGR LFLIFYGVIG VPFTLLTIAD LGMFLTRFLK NLLTMARRFA HYLVKLYQKA
     KKQRNKSQKT SPVMPDSERS EVWNTGKEMK EMSMRTAREP GEGDEIEVIE NGNDENGKEE
     DEEEPENNEP RKTEESIALG ITFTCYLVAG AKILSVYEPE MDFFKALYFN FVTLTTIGLG
     DFVPKSFDYL LITLIYIGIG LALTTMAIEI AADLLKKLHY IGRKMENVGQ AVVWFGGKKM
     TMKSLVKHLG DQFNIPEEEL ANFDMSAFVD NAIKVEKGEI ATLRKPPTPP VVFRERAFSF
     SNVRNSSESA LKYVDDNRFS KTTQPTIYTV IIHETTRTID TLHNLADAIR RDPSIPRLDL
     DVHYLTDMSA PTSFDENYLR TYTNARRK
 
 
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