ID   TWMF_TALWO              Reviewed;         549 AA.
AC   A0A2L0P0L8;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   25-APR-2018, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=MFS-type transporter TwmF {ECO:0000303|PubMed:29343058};
DE   AltName: Full=Wortmanamides biosynthesis cluster protein F {ECO:0000303|PubMed:29343058};
GN   Name=TwmF {ECO:0000303|PubMed:29343058};
GN   Synonyms=TwnF {ECO:0000303|PubMed:29343058};
OS   Talaromyces wortmannii (Penicillium wortmannii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Islandici.
OX   NCBI_TaxID=28567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 26942 / CBS 387.67 / CCM F-175 / VKM F-2091;
RX   PubMed=29343058; DOI=10.1021/jacs.7b13350;
RA   Hai Y., Tang Y.;
RT   "Biosynthesis of long-chain N-acyl amide by a truncated polyketide
RT   synthase-nonribosomal peptide synthetase hybrid megasynthase in fungi.";
RL   J. Am. Chem. Soc. 140:1271-1274(2018).
CC   -!- FUNCTION: MFS efflux transporter; part of the gene cluster that
CC       mediates the biosynthesis of wortmanamides A and B, reduced long-chain
CC       polyketides amidated with a specific omega-amino acid, 5-aminopentanoic
CC       acid (5PA). {ECO:0000269|PubMed:29343058}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; MG837523; AUY61974.1; -; Genomic_DNA.
DR   EMBL; MH399766; QBC19708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2L0P0L8; -.
DR   SMR; A0A2L0P0L8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..549
FT                   /note="MFS-type transporter TwmF"
FT                   /id="PRO_0000452492"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        502..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   549 AA;  59380 MW;  0EF73E3B384C2966 CRC64;
     MKSPSSSAEM QSSSPEPAPW KPDFQVYAIV IGLGITNLLA ALENTVLTIA APVVLTDLEL
     GENFIWVTNA FFLSSTAILP LFGQFSNIFG RRYVMLTAVA IFVLGSGLCG GASTGAMLIA
     GRAIQGVGSG GIIMLSSIII SDLVPLRQRG NFSAILMSIL GIGSALGPLI GGAIVSSISW
     RWVFYLNLPI GGVSFVFLFI FLRVKYNKEM TFWQKIKRID LVGNAIVIAS TVAILYALSY
     AGTRYPWRSW HTLVPLLVGF LGLFIFAGLQ TTAFSAEPLM PTRFFRAPTS IILAINTFVS
     AALLYWCLFF LPVFLQSVKL YSPRRAGVAL LPISLLGIPG SMVGAIALVR WGRYKPVHIF
     AFALQTLGLG LFTLFREDTS VAEWAVFQCI VAFGGGMIFT TMLPAFQAFI HERDIAACTA
     AWYFIRLFGH IWGVAIPAAI FNQRIDTLLG QGAISDPSVS KTIAAGGAYQ AASAAFVKQF
     PGSLQLEIRS VYSQAIQRVF QVSIAFAGVA FLLTLLEKDV GLRKTLETDF GLEKEGAGQQ
     ADVEGRSHE