TWSG1_CHICK
ID TWSG1_CHICK Reviewed; 224 AA.
AC Q98T89;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Twisted gastrulation protein homolog 1;
DE Flags: Precursor;
GN Name=TWSG1; Synonyms=TSG;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11260715; DOI=10.1038/35068572;
RA Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y.,
RA Greenspan D.S.;
RT "Homologues of Twisted gastrulation are extracellular cofactors in
RT antagonism of BMP signalling.";
RL Nature 410:475-478(2001).
RN [2]
RP ERRATUM OF PUBMED:11260715.
RA Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y.,
RA Greenspan D.S.;
RL Nature 411:720-720(2001).
CC -!- FUNCTION: May be involved in dorsoventral axis formation. Seems to
CC antagonize BMP signaling by forming ternary complexes with CHRD and
CC BMPs, thereby preventing BMPs from binding to their receptors. In
CC addition to the anti-BMP function, also has pro-BMP activity, partly
CC mediated by cleavage and degradation of CHRD, which releases BMPs from
CC ternary complexes. May be an important modulator of BMP-regulated
CC cartilage development and chondrocyte differentiation. May play a role
CC in thymocyte development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CHRD and BMP4. This interaction enhances
CC CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DOMAIN: The N-terminal domain is sufficient to interact with BMP4.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the twisted gastrulation protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF255731; AAK27324.1; -; mRNA.
DR RefSeq; NP_989529.1; NM_204198.1.
DR AlphaFoldDB; Q98T89; -.
DR STRING; 9031.ENSGALP00000013669; -.
DR PaxDb; Q98T89; -.
DR Ensembl; ENSGALT00000097473; ENSGALP00000065324; ENSGALG00000052629.
DR GeneID; 374024; -.
DR KEGG; gga:374024; -.
DR CTD; 57045; -.
DR VEuPathDB; HostDB:geneid_374024; -.
DR eggNOG; ENOG502QRE9; Eukaryota.
DR GeneTree; ENSGT00390000007058; -.
DR HOGENOM; CLU_082511_1_0_1; -.
DR InParanoid; Q98T89; -.
DR OMA; SCVDLCP; -.
DR OrthoDB; 1254178at2759; -.
DR PhylomeDB; Q98T89; -.
DR TreeFam; TF323922; -.
DR PRO; PR:Q98T89; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000052629; Expressed in colon and 14 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IBA:GO_Central.
DR InterPro; IPR006761; Tsg.
DR PANTHER; PTHR12312; PTHR12312; 1.
DR Pfam; PF04668; Tsg; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..224
FT /note="Twisted gastrulation protein homolog 1"
FT /id="PRO_0000278811"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 224 AA; 24904 MW; 42AD74E8A2DAC9F5 CRC64;
MRSPCAALSA SLLLLLLLLW ARSSVGCNKA LCASDVSKCL IQELCQCRPG EGNCSCCKEC
MLCLGTLWDE CCDCVGMCNP RNYSDTPPTS KSTVEELHEP IPSLFRALTE GDTQLNWNIV
SFPVAEELSH HENLVSFLET VNQPQHQNVS VPSNNIHAPY SSDKEHMCTV VYFDDCMSIH
QCKISCESMG ASKYRWFHNA CCECIGPECI DYGSKTVKCM NCMF
