ID   TWSG1_PONAB             Reviewed;         223 AA.
AC   Q5RAW4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Twisted gastrulation protein homolog 1;
DE   Flags: Precursor;
GN   Name=TWSG1; Synonyms=TSG;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in dorsoventral axis formation. Seems to
CC       antagonize BMP signaling by forming ternary complexes with CHRD and
CC       BMPs, thereby preventing BMPs from binding to their receptors. In
CC       addition to the anti-BMP function, also has pro-BMP activity, partly
CC       mediated by cleavage and degradation of CHRD, which releases BMPs from
CC       ternary complexes. May be an important modulator of BMP-regulated
CC       cartilage development and chondrocyte differentiation. May play a role
CC       in thymocyte development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHRD and BMP4. This interaction enhances
CC       CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal domain is sufficient to interact with BMP4.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the twisted gastrulation protein family.
CC       {ECO:0000305}.
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DR   EMBL; CR858897; CAH91096.1; -; mRNA.
DR   RefSeq; NP_001125639.1; NM_001132167.2.
DR   AlphaFoldDB; Q5RAW4; -.
DR   STRING; 9601.ENSPPYP00000010110; -.
DR   GeneID; 100172557; -.
DR   KEGG; pon:100172557; -.
DR   CTD; 57045; -.
DR   eggNOG; ENOG502QRE9; Eukaryota.
DR   InParanoid; Q5RAW4; -.
DR   OrthoDB; 1254178at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006761; Tsg.
DR   PANTHER; PTHR12312; PTHR12312; 1.
DR   Pfam; PF04668; Tsg; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..223
FT                   /note="Twisted gastrulation protein homolog 1"
FT                   /id="PRO_0000278810"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        81
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   223 AA;  25031 MW;  2D7D114B282BFD92 CRC64;
     MKLHYVAVLT LAILMFLTWL PASLSCNKAL CASDVSKCLI QELCQCRPGE GNCSCCKECM
     LCLEALWDEC CDCVGMCNPR NYSDTPPTSK STVEELHEPI PSLFRALTEG DTQLNWNIVS
     FPVAEELSHH ENLVSFLETV NQPHHQNVSV PSNNVHAPYS SDKEHMCTVV YFDDCMSIHQ
     CKISCESMGA SKYRWFHNAC CECIGPECID YGSKTVKCMN CMF