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C5AR1_RABIT
ID   C5AR1_RABIT             Reviewed;         350 AA.
AC   Q9TUE1;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=C5a anaphylatoxin chemotactic receptor 1;
DE   AltName: Full=C5a anaphylatoxin chemotactic receptor;
DE            Short=C5a-R;
DE            Short=C5aR;
DE   AltName: CD_antigen=CD88;
DE   Flags: Fragment;
GN   Name=C5AR1; Synonyms=C5R1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=New Zealand white;
RX   PubMed=10510441; DOI=10.1038/sj.bjp.0702812;
RA   Bachvarov D.R., Houle S., Bachvarova M., Bouthillier J., St Pierre S.A.,
RA   Fukuoka Y., Ember J.A., Marceau F.;
RT   "Cloning and preliminary pharmacological characterization of the
RT   anaphylatoxin C5a receptor in the rabbit.";
RL   Br. J. Pharmacol. 128:321-326(1999).
CC   -!- FUNCTION: Receptor for the chemotactic and inflammatory peptide
CC       anaphylatoxin C5a (PubMed:10510441). The ligand interacts with at least
CC       two sites on the receptor: a high-affinity site on the extracellular N-
CC       terminus, and a second site in the transmembrane region which activates
CC       downstream signaling events. Receptor activation stimulates chemotaxis,
CC       granule enzyme release, intracellular calcium release and superoxide
CC       anion production (By similarity). {ECO:0000250|UniProtKB:P21730,
CC       ECO:0000269|PubMed:10510441}.
CC   -!- SUBUNIT: Homodimer. May also form higher-order oligomers. Interacts
CC       (when phosphorylated) with ARRB1 and ARRB2; the interaction is
CC       associated with internalization of C5aR.
CC       {ECO:0000250|UniProtKB:P21730}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10510441};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P21730}. Cytoplasmic
CC       vesicle {ECO:0000250|UniProtKB:P21730}. Note=Phosphorylated C5aR
CC       colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
CC       {ECO:0000250|UniProtKB:P21730}.
CC   -!- PTM: Sulfation plays a critical role in the association of C5aR with
CC       C5a, but no significant role in the ability of the receptor to
CC       transduce a signal and mobilize calcium in response to a small peptide
CC       agonist. {ECO:0000250|UniProtKB:P21730}.
CC   -!- PTM: Phosphorylated on serine residues in response to C5a binding,
CC       resulting in internalization of the receptor and short-term
CC       desensitization to C5a. {ECO:0000250|UniProtKB:P21730}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF068680; AAF13030.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9TUE1; -.
DR   SMR; Q9TUE1; -.
DR   STRING; 9986.ENSOCUP00000023879; -.
DR   eggNOG; ENOG502R35Z; Eukaryota.
DR   InParanoid; Q9TUE1; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0045177; C:apical part of cell; ISS:UniProtKB.
DR   GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004878; F:complement component C5a receptor activity; ISS:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   InterPro; IPR001274; Anaphtx_C5AR1/C5AR2.
DR   InterPro; IPR002234; Anphylx_rcpt.
DR   InterPro; IPR000826; Formyl_rcpt-rel.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24225; PTHR24225; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01104; ANPHYLATOXNR.
DR   PRINTS; PR00426; C5ANPHYLTXNR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Cytoplasmic vesicle; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW   Receptor; Reference proteome; Sulfation; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..350
FT                   /note="C5a anaphylatoxin chemotactic receptor 1"
FT                   /id="PRO_0000069214"
FT   TOPO_DOM        <1..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        37..63
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        64..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        69..92
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        93..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        110..131
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        132..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        174..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        201..226
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        227..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        243..265
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        266..282
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        283..303
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   TOPO_DOM        304..350
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   MOD_RES         10
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         13
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         314
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         317
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         327
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         332
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         334
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   MOD_RES         338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21730"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        108..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   NON_TER         1
SQ   SEQUENCE   350 AA;  38586 MW;  C69871B3E20897C2 CRC64;
     APMENSTYDY TNYDSLGTLD PSTPVDNTVR RLRPTTIVAL VIYMAVFLVG VPGNALVVWV
     TALEAKRTVN AIWFLNLAVA DLLSCLALPI LFVSIIQEGH WPFGRAACSV LPSLILLNMY
     ASILLLATIS ADRFLLVFNP IWCQNTRGAG LAWLACCVAW GLALLLTIPS FLYRKVLQDD
     YPPKTTCGVD YGHEGVRAER AVAIVRLVVG FLLPLFTLSV CYTFLLLRTW SRNGTRSTKT
     LKVVVAVVVS FFIFWLPYQV MGMILALLHP SSATFRWAIR LDPLCIALAY VNCCINPIIY
     VVAGKGFQGQ LRKSLPSLLR NVLAEESVIQ GSKSFSRSTV DTVADKCQAV
 
 
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