ID   TX10A_CYRSC             Reviewed;          74 AA.
AC   B3FIU2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=U12-theraphotoxin-Hs1a;
DE            Short=U12-TRTX-Hs1a;
DE   AltName: Full=Huwentoxin-10a;
DE   AltName: Full=Huwentoxin-Xa;
DE            Short=HwTx-Xa;
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- FUNCTION: Putative ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 35 family.
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DR   EMBL; EU195286; ABY77739.1; -; mRNA.
DR   AlphaFoldDB; B3FIU2; -.
DR   SMR; B3FIU2; -.
DR   ArachnoServer; AS000656; U12-theraphotoxin-Hs1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..40
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000379920"
FT   PEPTIDE         41..74
FT                   /note="U12-theraphotoxin-Hs1a"
FT                   /id="PRO_0000379921"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   74 AA;  8222 MW;  B19759E196A08C05 CRC64;
     MNVKILLLLV GLNLVMHSNA TGDSETNPAE TLFIEEIFRR GCFKEGKWCP KSAPCCAPLK
     CKGPSIKQQK CVRE