ID   TX10C_MANRB             Reviewed;          82 AA.
AC   A0A6G9KHD6;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=U10-myrmicitoxin-Mri1c {ECO:0000303|PubMed:32182430};
DE            Short=U10-MYRTX-Mri1c {ECO:0000303|PubMed:32182430};
DE   Flags: Precursor;
OS   Manica rubida (European giant red ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Manica.
OX   NCBI_TaxID=219785 {ECO:0000312|EMBL:QIQ51445.1};
RN   [1] {ECO:0000312|EMBL:QIQ51445.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, TOXIC DOSE, MASS SPECTROMETRY, AND AMIDATION AT ILE-81.
RC   TISSUE=Venom gland {ECO:0000312|EMBL:QIQ51445.1};
RX   PubMed=32182430; DOI=10.1021/acs.jproteome.0c00048;
RA   Touchard A., Aili S.R., Tene N., Barasse V., Klopp C., Dejean A.,
RA   Kini R.M., Mrinalini X., Coquet L., Jouenne T., Lefranc B., Leprince J.,
RA   Escoubas P., Nicholson G.M., Treilhou M., Bonnafe E.;
RT   "Venom Peptide Repertoire of the European Myrmicine Ant Manica rubida:
RT   Identification of Insecticidal Toxins.";
RL   J. Proteome Res. 19:1800-1811(2020).
CC   -!- FUNCTION: Induces paralysis 5 minutes after injection into blowflies
CC       (L.caesar) (PubMed:32182430). In most cases is not lethal 24 hours
CC       after injection, but paralysis is irreversible (PubMed:32182430). May
CC       have antimicrobial properties, like most ant linear peptides (By
CC       similarity). {ECO:0000250|UniProtKB:Q07932,
CC       ECO:0000269|PubMed:32182430}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32182430}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:32182430}.
CC   -!- MASS SPECTROMETRY: Mass=2840.8; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:32182430};
CC   -!- TOXIC DOSE: PD(50) is 10.53 +-1.7 nmol/g in blowfly (L.caesar) (at 1
CC       hour post-injection). {ECO:0000269|PubMed:32182430}.
CC   -!- TOXIC DOSE: PD(50) is 29.25 +-2.0 nmol/g in blowfly (L.caesar) (at 24
CC       hours post-injection). {ECO:0000269|PubMed:32182430}.
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MN765035; QIQ51445.1; -; mRNA.
DR   AlphaFoldDB; A0A6G9KHD6; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0035738; P:envenomation resulting in modulation of process in another organism; IDA:UniProtKB.
DR   GO; GO:0044616; P:modulation of relaxation of muscle in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antimicrobial; Secreted; Signal; Toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..52
FT                   /evidence="ECO:0000305|PubMed:32182430"
FT                   /id="PRO_0000453063"
FT   PEPTIDE         53..81
FT                   /note="U10-myrmicitoxin-Mri1c"
FT                   /evidence="ECO:0000269|PubMed:32182430"
FT                   /id="PRO_0000453064"
FT   MOD_RES         81
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000305|PubMed:32182430"
SQ   SEQUENCE   82 AA;  8201 MW;  3E62FA22FB4E025C CRC64;
     MRLSYVSLTL AIIFVMAIVH APETEAKAYP EADAVGEASA VGEADAVGVA DPGVGSLLAK
     AALKILKIVA PAAAEVIANK IG