ID   TX115_PHYSE             Reviewed;          23 AA.
AC   P84851;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Nephrotoxin PsTX-115 {ECO:0000303|PubMed:17600120};
DE   Flags: Fragments;
OS   Phyllodiscus semoni (Night anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Aliciidae; Phyllodiscus.
OX   NCBI_TaxID=163701;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=17600120; DOI=10.2353/ajpath.2007.060984;
RA   Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan B.P.,
RA   Matsuo S.;
RT   "A protein toxin from the sea anemone Phyllodiscus semoni targets the
RT   kidney and causes a severe renal injury with predominant glomerular
RT   endothelial damage.";
RL   Am. J. Pathol. 171:402-414(2007).
CC   -!- FUNCTION: Nephrotoxin. When injected intravenously in rats, causes
CC       severe destructive glomerular changes. At 24 hours post-injection
CC       partial disruption of the glomerular basement membrane, massive
CC       thrombus formation in glomerular capillaries, severe mesangiolysis and
CC       infiltrating cells were observed in the majority of glomeruli.
CC       {ECO:0000269|PubMed:17600120}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17600120}.
CC       Nematocyst {ECO:0000269|PubMed:17600120}.
CC   -!- CAUTION: The order of the peptides shown is unknown. {ECO:0000305}.
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DR   AlphaFoldDB; P84851; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Nematocyst; Secreted; Toxin.
FT   CHAIN           <1..>23
FT                   /note="Nephrotoxin PsTX-115"
FT                   /id="PRO_0000235831"
FT   NON_CONS        12..13
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         23
SQ   SEQUENCE   23 AA;  2695 MW;  A8BE3A9242614EA8 CRC64;
     RDFTHTIIDN SDLFSESRNT RLG