ID   TX11A_ETHRU             Reviewed;         119 AA.
AC   P0DPW4;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=U-scoloptoxin(01)-Er1a {ECO:0000303|PubMed:24847043};
DE            Short=U-SLPTX(01)-Er1a {ECO:0000303|PubMed:24847043};
DE   Flags: Precursor;
OS   Ethmostigmus rubripes (Giant centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Ethmostigmus.
OX   NCBI_TaxID=62613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RC   TISSUE=Venom gland;
RX   PubMed=24847043; DOI=10.1093/molbev/msu162;
RA   Undheim E.A., Jones A., Clauser K.R., Holland J.W., Pineda S.S., King G.F.,
RA   Fry B.G.;
RT   "Clawing through evolution: toxin diversification and convergence in the
RT   ancient lineage Chilopoda (centipedes).";
RL   Mol. Biol. Evol. 31:2124-2148(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24847043}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24847043}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the scoloptoxin-01 family. {ECO:0000305}.
CC   -!- CAUTION: All E.rubripes family members described in 'Undeheim et al.,
CC       2014' have not been imported into UniProtKB. Please, refer to this
CC       paper to access them. {ECO:0000305|PubMed:24847043}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/GASI01000092";
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DR   AlphaFoldDB; P0DPW4; -.
DR   SMR; P0DPW4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002557; Chitin-bd_dom.
DR   InterPro; IPR036508; Chitin-bd_dom_sf.
DR   Pfam; PF01607; CBM_14; 1.
DR   SMART; SM00494; ChtBD2; 1.
DR   SUPFAM; SSF57625; SSF57625; 1.
DR   PROSITE; PS50940; CHIT_BIND_II; 1.
PE   3: Inferred from homology;
KW   Chitin-binding; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..119
FT                   /note="U-scoloptoxin(01)-Er1a"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000446688"
FT   DOMAIN          39..97
FT                   /note="Chitin-binding type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT   DISULFID        74..87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
SQ   SEQUENCE   119 AA;  13131 MW;  E3E122FC23D35B0D CRC64;
     MEIHSNIILL LLIALFAIFV KMEDEEKPPN LTRMPEGVNF ACSGKKPGFY ADEGFDCQVY
     HMCSPEGQLT TYLCGPGTIF NQKKLVCDLP TNYNCADAAK DAEEANANVF KTQSSTSEP