ID   TX12A_MYRGU             Reviewed;          84 AA.
AC   P0DSJ5;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=U-myrmeciitoxin(01)-Mg2a {ECO:0000305};
DE            Short=MIITX(01)-Mg2a {ECO:0000303|PubMed:30214940};
DE            Short=U-MIITX(01)-Mg2a {ECO:0000305};
DE   Flags: Precursor;
OS   Myrmecia gulosa (Red bulldog ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmeciinae; Myrmeciini; Myrmecia.
OX   NCBI_TaxID=36170;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND
RP   SUBUNIT.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=30214940; DOI=10.1126/sciadv.aau4640;
RA   Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R.,
RA   Payne R.J., Vetter I., King G.F., Undheim E.A.B.;
RT   "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia
RT   gulosa, reveals a hyperdiverse hymenopteran toxin gene family.";
RL   Sci. Adv. 4:EAAU4640-EAAU4640(2018).
CC   -!- FUNCTION: Causes cytolysis of mouse DRG neurons, proved by a drop in
CC       calcium concentration in all cells and a corresponding increase in
CC       fluorescence of the extracellular medium after toxin addition
CC       (PubMed:30214940). May be one of the major contributors to the pain
CC       associated with envenomation (PubMed:30214940). May have antimicrobial
CC       properties, like most ant linear peptides.
CC       {ECO:0000269|PubMed:30214940, ECO:0000305}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:30214940}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30214940}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:30214940}.
CC   -!- MASS SPECTROMETRY: Mass=8482.78; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:30214940};
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/GGFG01000002";
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DR   AlphaFoldDB; P0DSJ5; -.
DR   SMR; P0DSJ5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Antimicrobial; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..47
FT                   /evidence="ECO:0000305|PubMed:30214940"
FT                   /id="PRO_0000447067"
FT   CHAIN           48..84
FT                   /note="U-myrmeciitoxin(01)-Mg2a"
FT                   /evidence="ECO:0000269|PubMed:30214940"
FT                   /id="PRO_0000447068"
SQ   SEQUENCE   84 AA;  9064 MW;  4816F63CE1C629FC CRC64;
     MKTVILLLVL ALTVAIIIPT INGESVATAI SDSEAEPLAE SFAEPLALLS KDQALKHVWG
     VLKKLGKAAM EYVIQQICAK YNKK