ID   TX13A_MANRB             Reviewed;          57 AA.
AC   A0A6G9KIT6;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=U13-myrmicitoxin-Mri1a {ECO:0000303|PubMed:32182430};
DE            Short=U13-MYRTX-Mri1a {ECO:0000303|PubMed:32182430};
DE   Flags: Precursor;
OS   Manica rubida (European giant red ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Manica.
OX   NCBI_TaxID=219785 {ECO:0000312|EMBL:QIQ51451.1};
RN   [1] {ECO:0000312|EMBL:QIQ51451.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, TOXIC DOSE, AND AMIDATION AT GLU-56.
RC   TISSUE=Venom gland {ECO:0000312|EMBL:QIQ51451.1};
RX   PubMed=32182430; DOI=10.1021/acs.jproteome.0c00048;
RA   Touchard A., Aili S.R., Tene N., Barasse V., Klopp C., Dejean A.,
RA   Kini R.M., Mrinalini X., Coquet L., Jouenne T., Lefranc B., Leprince J.,
RA   Escoubas P., Nicholson G.M., Treilhou M., Bonnafe E.;
RT   "Venom Peptide Repertoire of the European Myrmicine Ant Manica rubida:
RT   Identification of Insecticidal Toxins.";
RL   J. Proteome Res. 19:1800-1811(2020).
CC   -!- FUNCTION: Induces paralysis 1 hour after injection into blowflies
CC       (L.caesar) but does not appear to be lethal.
CC       {ECO:0000269|PubMed:32182430}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32182430}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:32182430}.
CC   -!- MASS SPECTROMETRY: Mass=2978.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:32182430};
CC   -!- TOXIC DOSE: PD(50) is 2.9 +-0.9 nmol/g in blowfly (L.caesar) (at 1 hour
CC       post-injection). {ECO:0000269|PubMed:32182430}.
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DR   EMBL; MN765041; QIQ51451.1; -; mRNA.
DR   AlphaFoldDB; A0A6G9KIT6; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0035738; P:envenomation resulting in modulation of process in another organism; IDA:UniProtKB.
DR   GO; GO:0044616; P:modulation of relaxation of muscle in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antimicrobial; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..29
FT                   /evidence="ECO:0000305|PubMed:32182430"
FT                   /id="PRO_0000453065"
FT   PEPTIDE         30..56
FT                   /note="U13-myrmicitoxin-Mri1a"
FT                   /evidence="ECO:0000269|PubMed:32182430"
FT                   /id="PRO_0000453066"
FT   MOD_RES         56
FT                   /note="Glutamic acid 1-amide"
FT                   /evidence="ECO:0000305|PubMed:32182430"
SQ   SEQUENCE   57 AA;  6058 MW;  17F128DB53A836E3 CRC64;
     MKIIHVLLLV AVVAITMSPS IMAESVAEAD KPGQAKKIGL FDQIDKAAAA FMKLFEG