ID   TX13_KUKHI              Reviewed;          74 AA.
AC   P60979;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Omega-filistatoxin-Kh1a;
DE            Short=Omega-FLTX-Kh1a;
DE   AltName: Full=Toxin DW13.3;
OS   Kukulcania hibernalis (Southern house spider) (Filistata hibernalis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Haplogynae; Filistatoidea; Filistatidae; Kukulcania.
OX   NCBI_TaxID=268415;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=9687583; DOI=10.1124/mol.54.2.407;
RA   Sutton K.G., Siok C., Stea A., Zamponi G.W., Heck S.D., Volkmann R.A.,
RA   Ahlijanian M.K., Snutch T.P.;
RT   "Inhibition of neuronal calcium channels by a novel peptide spider toxin,
RT   DW13.3.";
RL   Mol. Pharmacol. 54:407-418(1998).
CC   -!- FUNCTION: Potently blocks vertebrate calcium channels Cav1 and Cav2. Is
CC       the most active on Cav2.2/CACNA1B (from HEK) (IC(50)=2.3 nM), followed
CC       by Cav2.1/CACNA1A (IC(50)=4.3 nM), Cav2.2/CACNA1B (from oocyte)
CC       (IC(50)=14.4 nM), Cav1.2/CACNA1C (IC(50)=26.8 nM), and Cav2.3/CACNA1E
CC       (IC(50)=96.4 nM). {ECO:0000269|PubMed:9687583}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 6 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=8668; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:9687583};
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DR   AlphaFoldDB; P60979; -.
DR   ArachnoServer; AS000211; omega-filistatoxin-Kh1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..74
FT                   /note="Omega-filistatoxin-Kh1a"
FT                   /id="PRO_0000087681"
SQ   SEQUENCE   74 AA;  8680 MW;  F91D4907EFEAD4D3 CRC64;
     AECLMIGDTS CVPRLGRRCC YGAWCYCDQQ LSCRRVGRKR ECGWVEVNCK CGWSWSQRID
     DWRADYSCKC PEDQ