ID   C5I3_DERAN              Reviewed;         102 AA.
AC   A0A146B485; A0A158RFT3;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   08-JUN-2016, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=Complement inhibitor RaCI3 {ECO:0000303|PubMed:27018802};
DE   Flags: Precursor;
OS   Dermacentor andersoni (Rocky mountain wood tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Dermacentor.
OX   NCBI_TaxID=34620;
RN   [1] {ECO:0000312|EMBL:DAA64995.1, ECO:0007744|PDB:5HCC}
RP   NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF
RP   25-102 IN COMPLEX WITH HUMAN COMPLEMENT C5 AND THE TICK COMPLEMENT
RP   INHBIBITOR OMCI, FUNCTION, AND DISULFIDE BOND.
RC   TISSUE=Salivary gland;
RX   PubMed=27018802; DOI=10.1038/nsmb.3196;
RA   Jore M.M., Johnson S., Sheppard D., Barber N.M., Li Y.I., Nunn M.A.,
RA   Elmlund H., Lea S.M.;
RT   "Structural basis for therapeutic inhibition of complement C5.";
RL   Nat. Struct. Mol. Biol. 23:378-386(2016).
RN   [2]
RP   FUNCTION.
RX   PubMed=31871188; DOI=10.1073/pnas.1909973116;
RA   Reichhardt M.P., Johnson S., Tang T., Morgan T., Tebeka N., Popitsch N.,
RA   Deme J.C., Jore M.M., Lea S.M.;
RT   "An inhibitor of complement C5 provides structural insights into
RT   activation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:362-370(2020).
CC   -!- FUNCTION: Complement inhibitor (PubMed:27018802). Prevents complement-
CC       mediated C5 activation by binding to C5 (PubMed:27018802). Binds C5 at
CC       a different binding site than the other tick complement inbibitors OmCI
CC       and CirpT1, and the drug eculizumab (PubMed:27018802, PubMed:31871188).
CC       Inhibits complement in human and guinea pig but not in other species
CC       tested (rabbit, rat, mouse, and pig) (PubMed:27018802).
CC       {ECO:0000269|PubMed:27018802, ECO:0000269|PubMed:31871188}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27018802}.
CC   -!- TISSUE SPECIFICITY: Expressed by salivary glands.
CC       {ECO:0000305|PubMed:27018802}.
CC   -!- SIMILARITY: Belongs to the RaCI family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BK009406; DAA64995.1; -; mRNA.
DR   EMBL; EG364159; -; NOT_ANNOTATED_CDS; mRNA.
DR   PDB; 5HCC; X-ray; 2.59 A; D=25-102.
DR   PDBsum; 5HCC; -.
DR   SMR; A0A146B485; -.
PE   1: Evidence at protein level;
KW   3D-structure; Complement system impairing toxin; Disulfide bond; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..102
FT                   /note="Complement inhibitor RaCI3"
FT                   /id="PRO_5007523338"
FT   DISULFID        37..61
FT                   /evidence="ECO:0000269|PubMed:27018802,
FT                   ECO:0007744|PDB:5HCC"
FT   DISULFID        42..63
FT                   /evidence="ECO:0000269|PubMed:27018802,
FT                   ECO:0007744|PDB:5HCC"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000269|PubMed:27018802,
FT                   ECO:0007744|PDB:5HCC"
SQ   SEQUENCE   102 AA;  10936 MW;  EEFE16E26B95C62F CRC64;
     MAALNGLVLL LLTISAMFIS ECYSSGESQS IQRKGQCEEV ICHRKLNHLG ERVTSGCPTG
     CLCVIREPDN VDNANGTCYA LMSSTTTTTT TPDGTTTSEE EE