ID   C5I4_HYARU              Reviewed;          96 AA.
AC   E2J6T4;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 11.
DE   RecName: Full=Complement inhibitor RaCI4 {ECO:0000303|PubMed:27018802};
DE   Flags: Precursor;
OS   Hyalomma rufipes (Tick) (Hyalomma marginatum rufipes).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Hyalomminae; Hyalomma.
OX   NCBI_TaxID=72862;
RN   [1] {ECO:0000312|EMBL:ADN23522.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=21851864; DOI=10.1016/j.jprot.2011.07.015;
RA   Francischetti I.M., Anderson J.M., Manoukis N., Pham V.M., Ribeiro J.M.;
RT   "An insight into the sialotranscriptome and proteome of the coarse
RT   bontlegged tick, Hyalomma marginatum rufipes.";
RL   J. Proteomics 74:2892-2908(2011).
RN   [2] {ECO:0000312|EMBL:DAA64996.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=27018802; DOI=10.1038/nsmb.3196;
RA   Jore M.M., Johnson S., Sheppard D., Barber N.M., Li Y.I., Nunn M.A.,
RA   Elmlund H., Lea S.M.;
RT   "Structural basis for therapeutic inhibition of complement C5.";
RL   Nat. Struct. Mol. Biol. 23:378-386(2016).
CC   -!- FUNCTION: Complement inhibitor (PubMed:27018802). Prevents complement-
CC       mediated C5 activation by binding to C5 (PubMed:27018802). Binds C5 at
CC       a different binding site than the other tick complement inbibitors OmCI
CC       and CirpT1, and the drug eculizumab (By similarity). Inhibits
CC       complement in human and guinea pig but not in other species tested
CC       (rabbit, rat, mouse, and pig) (PubMed:27018802).
CC       {ECO:0000250|UniProtKB:A0A146B485, ECO:0000269|PubMed:27018802}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27018802}.
CC   -!- TISSUE SPECIFICITY: Expressed by salivary glands.
CC       {ECO:0000305|PubMed:27018802}.
CC   -!- SIMILARITY: Belongs to the RaCI family. {ECO:0000305}.
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DR   EMBL; HP429127; ADN23522.1; -; mRNA.
DR   EMBL; BK009407; DAA64996.1; -; mRNA.
DR   EMBL; GR908966; -; NOT_ANNOTATED_CDS; mRNA.
PE   3: Inferred from homology;
KW   Complement system impairing toxin; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..96
FT                   /note="Complement inhibitor RaCI4"
FT                   /id="PRO_5010961975"
FT   DISULFID        37..61
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
FT   DISULFID        42..63
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000250|UniProtKB:A0A146B485"
SQ   SEQUENCE   96 AA;  10299 MW;  B2AA44A939B367BF CRC64;
     MSAFNIFALV VVVCALMINE CCTSQEPTTP LKAASQCSNV KCRRRFDHLG NSVTEGCPSG
     CLCVYQATGY NQEANGTCYE LMKTSTTTTT EGTPAQ