ID   TX16A_ODOMO             Reviewed;          81 AA.
AC   A0A348G5W2;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2018, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=U-poneritoxin(01)-Om6a {ECO:0000305};
DE            Short=PONTX(01)-Om6 {ECO:0000303|PubMed:30214940};
DE            Short=U-PONTX(01)-Om6a {ECO:0000305};
DE   AltName: Full=Pilosulin-like peptide 6 {ECO:0000312|EMBL:BBF97835.1};
DE            Short=PLP6 {ECO:0000303|PubMed:29027956};
DE   AltName: Full=Poneratoxin {ECO:0000305};
DE   Flags: Precursor;
OS   Odontomachus monticola (Trap-jaw ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Odontomachus.
OX   NCBI_TaxID=613454;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND
RP   PROBABLE AMIDATION AT ALA-79.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=29027956; DOI=10.3390/toxins9100323;
RA   Kazuma K., Masuko K., Konno K., Inagaki H.;
RT   "Combined venom gland transcriptomic and venom peptidomic analysis of the
RT   predatory ant Odontomachus monticola.";
RL   Toxins 9:323-323(2017).
RN   [2]
RP   FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SYNTHESIS OF PEPTIDE WITH
RP   UNKNOWN TERMINAL RESIDUES, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=30658410; DOI=10.3390/toxins11010050;
RA   Tani N., Kazuma K., Ohtsuka Y., Shigeri Y., Masuko K., Konno K.,
RA   Inagaki H.;
RT   "Mass spectrometry analysis and biological characterization of the
RT   predatory ant Odontomachus monticola venom and venom sac components.";
RL   Toxins 11:0-0(2019).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=30214940; DOI=10.1126/sciadv.aau4640;
RA   Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R.,
RA   Payne R.J., Vetter I., King G.F., Undheim E.A.B.;
RT   "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia
RT   gulosa, reveals a hyperdiverse hymenopteran toxin gene family.";
RL   Sci. Adv. 4:EAAU4640-EAAU4640(2018).
CC   -!- FUNCTION: Cationic amphipathic alpha-helical peptide with antimicrobial
CC       activities against E.coli (MIC=3.1), and S.aureus (MIC=3.1 uM). Also
CC       shows histamine-releasing activity (33.6% at 10 uM). Does not have
CC       activity against S.cerevisiae. Does not show hemolytic activity, even
CC       at 50 uM. {ECO:0000269|PubMed:30658410}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29027956}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29027956}.
CC   -!- PTM: Truncated sequences of this peptide have also been found in the
CC       venom. It is possible they have been cleaved in the venom.
CC       {ECO:0000305|PubMed:30658410}.
CC   -!- MASS SPECTROMETRY: Mass=3704.235; Method=Electrospray;
CC       Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:29027956};
CC   -!- SIMILARITY: Belongs to the formicidae venom precursor-01 superfamily.
CC       {ECO:0000305}.
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DR   EMBL; FX985499; BBF97835.1; -; mRNA.
DR   AlphaFoldDB; A0A348G5W2; -.
DR   SMR; A0A348G5W2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..43
FT                   /evidence="ECO:0000305|PubMed:29027956"
FT                   /id="PRO_0000447086"
FT   PEPTIDE         44..79
FT                   /note="U-poneritoxin(01)-Om6a"
FT                   /evidence="ECO:0000269|PubMed:30658410"
FT                   /id="PRO_5016781678"
FT   MOD_RES         79
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000305|PubMed:29027956"
SQ   SEQUENCE   81 AA;  8342 MW;  C2C46FC1F3E757FE CRC64;
     MRRSYVLLAF AIVLIISIIS AQVEADASSD AFADAVADAV ADPIKGKKIM KNMGKAMKIA
     GKVAKAMAPI VVPLIVSAAG K