ID   C5I5_RHIAP              Reviewed;          95 AA.
AC   A0A141SFN5;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   08-JUN-2016, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=Complement inhibitor RaCI5 {ECO:0000303|PubMed:27018802};
DE   AltName: Full=Rhipicephalus appendiculatus complement inhibitor 5 {ECO:0000312|EMBL:AML25524.1};
DE   Flags: Precursor;
OS   Rhipicephalus appendiculatus (Brown ear tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Rhipicephalus.
OX   NCBI_TaxID=34631;
RN   [1] {ECO:0000312|EMBL:AML25524.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=27018802; DOI=10.1038/nsmb.3196;
RA   Jore M.M., Johnson S., Sheppard D., Barber N.M., Li Y.I., Nunn M.A.,
RA   Elmlund H., Lea S.M.;
RT   "Structural basis for therapeutic inhibition of complement C5.";
RL   Nat. Struct. Mol. Biol. 23:378-386(2016).
CC   -!- FUNCTION: Complement inhibitor (PubMed:27018802). Prevents complement-
CC       mediated C5 activation by binding to C5 (By similarity). Binds C5 at a
CC       different binding site than the other tick complement inbibitors OmCI
CC       and CirpT1, and the drug eculizumab (By similarity).
CC       {ECO:0000250|UniProtKB:A0A146B485, ECO:0000250|UniProtKB:A0A182DWE4,
CC       ECO:0000269|PubMed:27018802}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27018802}.
CC   -!- TISSUE SPECIFICITY: Expressed by salivary glands.
CC       {ECO:0000305|PubMed:27018802}.
CC   -!- SIMILARITY: Belongs to the RaCI family. {ECO:0000305}.
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DR   EMBL; KU533795; AML25524.1; -; mRNA.
PE   3: Inferred from homology;
KW   Complement system impairing toxin; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..95
FT                   /note="Complement inhibitor RaCI5"
FT                   /id="PRO_5007492723"
FT   DISULFID        35..59
FT                   /evidence="ECO:0000250|UniProtKB:A0A182DWE4"
FT   DISULFID        40..61
FT                   /evidence="ECO:0000250|UniProtKB:A0A182DWE4"
FT   DISULFID        55..76
FT                   /evidence="ECO:0000250|UniProtKB:A0A182DWE4"
SQ   SEQUENCE   95 AA;  9978 MW;  C5A5A505F6C6762F CRC64;
     MNAVIVLCVT ISAVLIHQCY STAEATLSIN GGDMCIEKTC NRSIDAAGKK VIAGCPGGCL
     CVFNVSDVTY PANGTCYQLA TTTTNRPGAV MERER