ID   TX16C_CYRSC             Reviewed;         113 AA.
AC   B3FIQ7;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=U10-theraphotoxin-Hs2a;
DE            Short=U10-TRTX-Hs2a;
DE   AltName: Full=HWTX-XVIc {ECO:0000303|PubMed:18482741};
DE   Flags: Precursor;
OS   Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Cyriopagopus.
OX   NCBI_TaxID=29017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18482741; DOI=10.1016/j.toxicon.2008.03.024;
RA   Jiang L., Peng L., Chen J., Zhang Y., Xiong X., Liang S.;
RT   "Molecular diversification based on analysis of expressed sequence tags
RT   from the venom glands of the Chinese bird spider Ornithoctonus huwena.";
RL   Toxicon 51:1479-1489(2008).
CC   -!- FUNCTION: Probable ion channel inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0CH73}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 02 (HWTX-
CC       XVIc) subfamily. {ECO:0000305}.
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DR   EMBL; EU195251; ABY77704.1; -; mRNA.
DR   AlphaFoldDB; B3FIQ7; -.
DR   ArachnoServer; AS000510; U10-theraphotoxin-Hs2a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012627; Toxin_22.
DR   Pfam; PF08092; Toxin_22; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..67
FT                   /evidence="ECO:0000250|UniProtKB:P0CH73"
FT                   /id="PRO_0000435165"
FT   CHAIN           68..113
FT                   /note="U10-theraphotoxin-Hs2a"
FT                   /id="PRO_5002788384"
FT   DISULFID        68..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        75..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..106
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  13131 MW;  4CFD76A0E967B62A CRC64;
     MNTVRVTFLL VFVLAVSLGQ ADEDGNRMEK RQKKTEAENL LLPKLEELDA KLWEEDSVES
     RNSRQKRCNG KDVPCDPDPA KNRRCCSGLE CLKPYLHGIW YQDYYCYVEK SGR