ID   TX17_PHORI              Reviewed;          32 AA.
AC   P84016;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=U6-ctenitoxin-Pr1a;
DE            Short=U6-CNTX-Pr1a;
DE   AltName: Full=Venom protein PRTx17C1;
OS   Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=272752;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|PubMed:16278100};
RX   PubMed=16278100; DOI=10.1016/j.cbpc.2005.09.010;
RA   Richardson M., Pimenta A.M., Bemquerer M.P., Santoro M.M., Beirao P.S.,
RA   Lima M.E., Figueiredo S.G., Bloch C. Jr., Vasconcelos E.A., Campos F.A.,
RA   Gomes P.C., Cordeiro M.N.;
RT   "Comparison of the partial proteomes of the venoms of Brazilian spiders of
RT   the genus Phoneutria.";
RL   Comp. Biochem. Physiol. 142:173-187(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16278100}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16278100}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3465.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16278100};
CC   -!- SIMILARITY: Belongs to the neurotoxin 17 (21C2) family. {ECO:0000305}.
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DR   AlphaFoldDB; P84016; -.
DR   SMR; P84016; -.
DR   ArachnoServer; AS000215; U6-ctenitoxin-Pr1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012634; Toxin_29.
DR   Pfam; PF08116; Toxin_29; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted.
FT   PEPTIDE         1..32
FT                   /note="U6-ctenitoxin-Pr1a"
FT                   /id="PRO_0000044975"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..30
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3472 MW;  3F636E83992B4734 CRC64;
     AFCRFNGQQC TSDGQCCNGR CINAFQGRIC IG