C5I6_DERAN
ID C5I6_DERAN Reviewed; 102 AA.
AC P0DQV0;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 1.
DT 03-AUG-2022, entry version 1.
DE RecName: Full=Complement inhibitor RaCI6 {ECO:0000303|PubMed:27018802};
DE Flags: Precursor;
OS Dermacentor andersoni (Rocky mountain wood tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Dermacentor.
OX NCBI_TaxID=34620;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Salivary gland;
RX PubMed=27018802; DOI=10.1038/nsmb.3196;
RA Jore M.M., Johnson S., Sheppard D., Barber N.M., Li Y.I., Nunn M.A.,
RA Elmlund H., Lea S.M.;
RT "Structural basis for therapeutic inhibition of complement C5.";
RL Nat. Struct. Mol. Biol. 23:378-386(2016).
CC -!- FUNCTION: Complement inhibitor (By similarity). Prevents complement-
CC mediated C5 activation by binding to C5 (By similarity). Binds C5 at a
CC different binding site than the other tick complement inbibitors OmCI
CC and CirpT1, and the drug eculizumab (By similarity).
CC {ECO:0000250|UniProtKB:A0A146B485}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27018802}.
CC -!- TISSUE SPECIFICITY: Expressed by salivary glands.
CC {ECO:0000305|PubMed:27018802}.
CC -!- SIMILARITY: Belongs to the RaCI family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EG363232; -; NOT_ANNOTATED_CDS; mRNA.
PE 3: Inferred from homology;
KW Complement system impairing toxin; Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..102
FT /note="Complement inhibitor RaCI6"
FT /id="PRO_0000456231"
FT DISULFID 37..61
FT /evidence="ECO:0000250|UniProtKB:A0A146B485"
FT DISULFID 42..63
FT /evidence="ECO:0000250|UniProtKB:A0A146B485"
SQ SEQUENCE 102 AA; 10742 MW; 6CC311AFFF822298 CRC64;
MAALNGLVLL LLTISAMFIS ECYSSGESQS IQRNGRCEEV TCQRKPNHLG VAVTSGCPPG
CLCVIQAPDN AVNANGTRYE LMTTTTTKTT TTSGTPSSED PE